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UniProtKB/Swiss-Prot entry Q41437

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH2_SOLTU
Primary accession number Q41437
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Synonyms HMG-CoA reductase 2
EC 1.1.1.34
HMG2.2
Gene name
Name: HMG2
From
Solanum tuberosum (Potato) [TaxID: 4113] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Kennebec;
TISSUE=Tuber;
DOI=10.1023/A:1005743011651; PubMed=9049274 [NCBI, ExPASy, EBI, Israel, Japan]
Korth K.L., Stermer B.A., Bhattacharyya M.K., Dixon R.A.;
"HMG-CoA reductase gene families that differentially accumulate transcripts in potato tubers are developmentally expressed in floral tissues.";
Plant Mol. Biol. 33:545-551(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U51985; AAB52551.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P04035; 1HWI. [HSSP ENTRY / PDB]
ModBase Q41437.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q41437.
Other
ProtoNet Q41437.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   595  595     3-hydroxy-3-methylglutaryl-coenzyme A reductase 2. PRO_0000114449
TRANSMEM   48    68  21     Potential. 
TRANSMEM   92   112  21     Potential. 
REGION   113   183  71     Linker (By similarity). 
REGION   184   595  412     Catalytic (By similarity). 
ACT_SITE   278   278        Charge relay system (By similarity). 
ACT_SITE   410   410        Charge relay system (By similarity). 
ACT_SITE   486   486        Charge relay system (By similarity). 
ACT_SITE   584   584        Proton donor (By similarity). 
CARBOHYD   35    35        N-linked (GlcNAc...) (Potential). 
CARBOHYD   121   121        N-linked (GlcNAc...) (Potential). 
CARBOHYD   342   342        N-linked (GlcNAc...) (Potential). 
CARBOHYD   455   455        N-linked (GlcNAc...) (Potential). 
CARBOHYD   588   588        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 595 AA [This is the length of the unprocessed precursor] Molecular weight: 63842 Da [This is the MW of the unprocessed precursor] CRC64: 0FA7069849D41D57 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDVRRRSEKP VYPSKVFGAD EKPLKPHNNQ QQEDNNTLLI DASDALPLPL YLTNGLFFTM 

        70         80         90        100        110        120 
FFSVMYFLLS RWREKIRNST PLHVVTLSEL GAIVSLIASV IYLLGFFGIG FVQTFVSRGN 

       130        140        150        160        170        180 
NDSWDENDEE FLLKEDSRCG PATTLGCAIP APPARQISPM APPQPAMSMV EKPSPLITPA 

       190        200        210        220        230        240 
SSEEDEEIIN SVVQGKFPSY SLVIQLGDVS AAASLRKEVM QRITGKSLEG LPLEGFTYES 

       250        260        270        280        290        300 
ILGQCCEMPI GYVQIPVGIA GPLLLNGKEF SVPMATTEGC LVASTNRGCK AIYASGGATC 

       310        320        330        340        350        360 
IVLRDGMTRA PCVRFGTAKR AAELKFFVED PIKFETLANV FNQSSRFGRL QRIQCAIAGK 

       370        380        390        400        410        420 
NLYMRFVCST GDAMGMNMVS KGVQNVLDYL QNEYPDMDVI GISGNFCSDK KPAAVNWIEG 

       430        440        450        460        470        480 
RGKSVVCEAI ITEEVVKKVL KTEVAALVEL NMLKNLTGSA MAGALGGFNA HASNIVSAVF 

       490        500        510        520        530        540 
IATGQDPAQN IESSHCITMM EAVNDGKDLH ISVTMPSIEV GTVGGGTQLA SQSACLNLLG 

       550        560        570        580        590 
VKGANREAPG SNARLLATVV AGSVLAGELS LMSAISAGQL VNSHMKYNRS TKASS
Q41437 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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