[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION. STRAIN=cv. Bridger; TISSUE=Leaf; DOI=10.1007/BF00019320; PubMed=7894018 [NCBI, ExPASy, EBI, Israel, Japan] Stroeher V.L., Boothe J.G., Good A.G.; "Molecular cloning and expression of a turgor-responsive gene in Brassica napus."; Plant Mol. Biol. 27:541-551(1995).
[2]	PROTEIN SEQUENCE OF 2-16. DOI=10.1016/S0014-5793(02)02553-X; PubMed=11959129 [NCBI, ExPASy, EBI, Israel, Japan] Tang W.-K., Cheng C.H.K., Fong W.-P.; "First purification of the antiquitin protein and demonstration of its enzymatic activity."; FEBS Lett. 516:183-186(2002).

Comments

CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
SUBUNIT: Homotetramer (By similarity).
INDUCTION: By water stress, low temperature, heat shock, high salt and abscisic acid.
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

S77096; AAB33843.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S53503; S53503.

3D structure databases

HSSP

P05091; 1O04. [HSSP ENTRY / PDB]

ModBase

Q41247.

Ontologies

GO:0004029;	Molecular function: aldehyde dehydrogenase (NAD) activity (non-traceable author statement from UniProtKB).
GO:0006081;	Biological process: cellular aldehyde metabolic process (non-traceable author statement from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00687; ALDEHYDE_DEHYDR_GLU; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; NAD; Oxidoreductase; Stress response.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 494`	`493`	`Aldehyde dehydrogenase family 7 member A1.`	`PRO_0000056496`
`NP_BIND`	`247 252`	`6`	`NAD (By similarity).`
`ACT_SITE`	`269 269`		`Proton acceptor (By similarity).`
`ACT_SITE`	`303 303`		`Nucleophile (By similarity).`
`SITE`	`168 168`	`1`	`Transition state stabilizer (By similarity).`

Sequence information

Length: 494 AA [This is the length of the unprocessed precursor]

Molecular weight: 52688 Da [This is the MW of the unprocessed precursor]

CRC64: 13ED0096563BAE13 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGSASKEYEF LSEIGLSSSH NLGNYVGGKW LGNGPLVSTL NPANNQVLPI AQVVEASLED 

        70         80         90        100        110        120 
YEIGLKACEE AAKTWMQVPA PKRGDIVRQI GDALRSKLDY LGRLLSLEMG KILAEGIGEV 

       130        140        150        160        170        180 
QEVIDMCDFA VGLSRQLNGS VIPSERPNHM MLEMWNPLGI VGVITAFNFP CAVLGWNACI 

       190        200        210        220        230        240 
ALVCGNCVVW KGAPTTPLIT IAMTKLVAEV LEKNHLPGAI FTAMCGGAEI GEAIAKDTRI 

       250        260        270        280        290        300 
PLVSFTGSSK VGLTVQQTVS ARSGKTLLEL SGNNAIIVMD DADIQLAARS VLFAAVGTAG 

       310        320        330        340        350        360 
QRCTTCRRLL LHESVYDKVL EQLLTSYKQV KIGDPLEKGT LLGPLHTPES KKNFEKGIEV 

       370        380        390        400        410        420 
IKSQGGKVLT GGKAVEGEGN FVEPTIIEIS SDAAVVKEEL FAPVLYALKF KTFEEAVAIN 

       430        440        450        460        470        480 
NSVPQGLSSS IFTRSPDNIF KWIGPMGSDC GIVNVNIPTN GAEIGGAFGG EKATGGGREA 

       490 
GSDSWKQYMR RSTW

Q41247 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools