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UniProtKB/Swiss-Prot entry Q40345

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDHP_MEDSA
Primary accession number Q40345
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 48)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP], chloroplastic [Precursor] [Fragment]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name None
From
Medicago sativa (Alfalfa) [TaxID: 3879] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids I; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1007/BF00027151; PubMed=1281435 [NCBI, ExPASy, EBI, Israel, Japan]
Shorrosh B.S., Dixon R.A.;
"Molecular characterization and expression of an isocitrate dehydrogenase from alfalfa (Medicago sativa L).";
Plant Mol. Biol. 20:801-807(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M93672; AAA32656.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S28423; S28423.
T09619; T09619.
3D structure databases
HSSP P33198; 1LWD. [HSSP ENTRY / PDB]
ModBase Q40345.
Family and domain databases
InterPro IPR004790; IsoCit_DHase_NADP-dep_euk.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11822; IDH_NADP_euk; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000108; IDH_NADP; 1.
ProDom PD328597; Nadp_idh_plant; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00127; nadp_idh_euk; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q40345.
Other
ProtoNet Q40345.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chloroplast; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Plastid; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   <1    21  >21     Chloroplast (By similarity). 
CHAIN   22   433  412     Isocitrate dehydrogenase [NADP], chloroplastic. PRO_0000014427
NP_BIND   98   100  3     NADP (By similarity). 
NP_BIND   333   338  6     NADP (By similarity). 
REGION   117   123  7     Substrate binding (By similarity). 
METAL   275   275        Magnesium or manganese (By similarity). 
METAL   298   298        Magnesium or manganese (By similarity). 
BINDING   100   100        Substrate (By similarity). 
BINDING   105   105        NADP (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   155   155        Substrate (By similarity). 
BINDING   283   283        NADP (By similarity). 
BINDING   351   351        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
SITE   162   162  1     Critical for catalysis (By similarity). 
SITE   235   235  1     Critical for catalysis (By similarity). 
NON_TER   1     1         
Sequence information
Length: 433 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 48383 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: E4421317B8A2CFE3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
QFSPNLSFSA FFPIITFTTA TMGFQKIKVA NPIVEMDGDE MTRIIWKYIK DKLIFPFVEL 

        70         80         90        100        110        120 
DIKYFDLGLP YRDETNDKVT VESAEATLKY NVAIKCATIT PDEARVKEFG LKSMWRSPNG 

       130        140        150        160        170        180 
TIRNILNGTV FREPIICKNI PRLIPGWTKP ICIGRHAFGD QYRATDSVIK GPGKLKLVFV 

       190        200        210        220        230        240 
PEGQGETTDL EVYNFTGEGG VALAMYNTDE SIRSFAEASM AVALEKKWPL YLSTKNTILK 

       250        260        270        280        290        300 
KYDGRFKDIF QEVYEAGWKS KYEAAGIWYE HRLIDDMVAY ALKSEGGYVW ACKNYDGDVQ 

       310        320        330        340        350        360 
SDFLAQGFGS LGLMTSVLVC PDGKTIEAEA AHGTVTRHFR VHQKGGETST NSIASIFAWT 

       370        380        390        400        410        420 
RGLAHRAKLD DNATLLDFTE KLEAACIGVV ESGKMTKDLA LILHGSKLSR EHYLNTEEFI 

       430 
DAVAAELKTK ISA
Q40345 in FASTA format

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