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UniProtKB/Swiss-Prot entry Q3Z878

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_DEHE1
Primary accession number Q3Z878
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on September 27, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 24)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: DET0844
From
Dehalococcoides ethenogenes (strain 195) [TaxID: 243164] [HAMAP proteome]
Taxonomy Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1102226; PubMed=15637277 [NCBI, ExPASy, EBI, Israel, Japan]
Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E., Kang K.H., Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H., Heidelberg J.F.;
"Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes.";
Science 307:105-108(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000027; AAW39898.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_181571.1; -.
3D structure databases
ModBase Q3Z878.
Enzyme and pathway databases
BioCyc DETH243164:DET_0844-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q3Z878.
Genome annotation databases
GeneID 3229860; -.
GenomeReviews CP000027_GR; DET0844.
KEGG det:DET0844; -.
NMPDR fig|243164.3.peg.943; -.
TIGR DET0844; -.
Phylogenomic databases
HOGENOM Q3Z878; -.
Other
ProtoNet Q3Z878.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   436  436     Histidinol dehydrogenase. PRO_0000135764
ACT_SITE   334   334        Proton acceptor (By similarity). 
ACT_SITE   335   335        Proton acceptor (By similarity). 
METAL   266   266        Zinc (By similarity). 
METAL   269   269        Zinc (By similarity). 
METAL   368   368        Zinc (By similarity). 
METAL   427   427        Zinc (By similarity). 
BINDING   136   136        NAD (By similarity). 
BINDING   198   198        NAD (By similarity). 
BINDING   221   221        NAD (By similarity). 
BINDING   244   244        Substrate (By similarity). 
BINDING   266   266        Substrate (By similarity). 
BINDING   269   269        Substrate (By similarity). 
BINDING   335   335        Substrate (By similarity). 
BINDING   368   368        Substrate (By similarity). 
BINDING   422   422        Substrate (By similarity). 
BINDING   427   427        Substrate (By similarity). 
Sequence information
Length: 436 AA [This is the length of the unprocessed precursor] Molecular weight: 46836 Da [This is the MW of the unprocessed precursor] CRC64: B5BDCD65764EA53F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEIIRGFAPA EKRLSRRDKA GFFLDETQRA ELAKRLGVDP EKAVNGIIDD IRKQGDKAVL 

        70         80         90        100        110        120 
EYTLKFDRAA ISKLEVSPAE IKQAAGEIPA ELFEALKLAA TQVRAYHHFQ KEAVWKAAEI 

       130        140        150        160        170        180 
MQGKQLIRPL ERVGLYVPGG KAFYPSTVLM TAIPAKEAGV DEIILVTPPG ADGKIPAPTL 

       190        200        210        220        230        240 
AAAYIAGVDK VFACGGAQAV AALAFGTKSI PKVDKICGPG NIFVTLAKKA VFGVVDIDGL 

       250        260        270        280        290        300 
QGPSEVLILA DQYANAEYCA SDILAQAEHD VLASPIMVTT SAELAKRVND IVETKAGSCA 

       310        320        330        340        350        360 
RKDIIRQSLR DNGLIAVVDN MDEAIKLANM YATEHLCLLV KDSEQYLSRI NHAGCIFYGE 

       370        380        390        400        410        420 
KASVVMGDYV AGPSHALPTS GTARFSSPLN ILDFVKYIDI VNVSKEEVTK LGKAAVTIAR 

       430 
AEGLECHAEA ALKRME
Q3Z878 in FASTA format

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