[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Testis; NIH - Mammalian Gene Collection (MGC) project; Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: (S)-lactate + NAD⁺ = pyruvate + NADH.
PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1 .
SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
CAUTION: It is uncertain whether Met-1 or Met-50 is the initiator.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC102557; AAI02558.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001030352.1; -.

UniGene

Bt.94959

3D structure databases

SMR

Q3T056; 51-381.

ModBase

Q3T056.

Family and domain databases

InterPro

IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000102; Lac_mal_DH; 1.

PRINTS

PR00086; LLDHDRGNASE.

TIGRFAMs

TIGR01771; L-LDH-NAD; 1.

PROSITE

PS00064; L_LDH; 1.

BLOCKS

Q3T056.

Genome annotation databases

GeneID

509519; -.

KEGG

bta:509519; -.

Phylogenomic databases

HOVERGEN

Q3T056; -.

Other

ProtoNet

Q3T056.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Glycolysis; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 381`	`381`	`L-lactate dehydrogenase A-like 6B.`	`PRO_0000239653`
`NP_BIND`	`101 106`	`6`	`NAD (By similarity).`
`ACT_SITE`	`242 242`		`Proton acceptor (By similarity).`
`BINDING`	`148 148`		`NAD (By similarity).`
`BINDING`	`155 155`		`Substrate (By similarity).`
`BINDING`	`187 187`		`NAD or substrate (By similarity).`
`BINDING`	`218 218`		`Substrate (By similarity).`
`BINDING`	`297 297`		`Substrate (By similarity).`

Sequence information

Length: 381 AA [This is the length of the unprocessed precursor]

Molecular weight: 41592 Da [This is the MW of the unprocessed precursor]

CRC64: B6510C30FD480668 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSWTVGILRA SQRAGTVRAN FLCLGMAPSP CPPAATPLGG AWAVAPASKM ATVKCELMKN 

        70         80         90        100        110        120 
FTSEEPVRNS KISIVGTGSV GMACAVSILL KGLSDELALV DVDEGRLKGE TMDLQHGSLF 

       130        140        150        160        170        180 
VKMPNIVSSR DYVVTANSNL VIITAGARQE KGETRLNLVQ RNVAIFKLMM SSIVQYSPRC 

       190        200        210        220        230        240 
KLIVVSNPVD ILTYVAWKLS AFPQNRVIGS GCNLDTARFR FLIGQRLSIH SESCHGWILG 

       250        260        270        280        290        300 
EHGDSSVPVW SGVNIAGVPL KELNLDIGTD KDPEQWKNVH KDVVASAYEI IKMKGYTYWA 

       310        320        330        340        350        360 
IGLSVADLTE SILKNLRRVH PVSTRIKGLY GINEEVFLSV PCILGESGIT DLIKVKLAPE 

       370        380 
EEARLQKSAK TLWDIQKELK F

Q3T056 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools