[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Testis; NIH - Mammalian Gene Collection (MGC) project; Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: (R)-3-hydroxybutanoate + NAD⁺ = acetoacetate + NADH.
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC102567; AAI02568.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001029660.1; -.

UniGene

Bt.1792

3D structure databases

SMR

Q3T046; 1-245.

ModBase

Q3T046.

Ontologies

GO:0003858;	Molecular function: 3-hydroxybutyrate dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; 1.

BLOCKS

Q3T046.

Genome annotation databases

Ensembl

ENSBTAG00000002526; Bos taurus. [Contig view]

GeneID

515321; -.

KEGG

bta:515321; -.

Phylogenomic databases

HOVERGEN

Q3T046; -.

Other

ProtoNet

Q3T046.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; NAD; Oxidoreductase; Phosphoprotein.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 245`	`245`	`3-hydroxybutyrate dehydrogenase type 2.`	`PRO_0000247551`
`NP_BIND`	`10 37`	`28`	`NAD (By similarity).`
`NP_BIND`	`180 184`	`5`	`NAD (By similarity).`
`ACT_SITE`	`147 147`		`Proton acceptor (By similarity).`
`BINDING`	`58 58`		`NAD (By similarity).`
`BINDING`	`144 144`		`Substrate (By similarity).`
`BINDING`	`151 151`		`NAD (By similarity).`
`BINDING`	`188 188`		`Substrate (By similarity).`
`BINDING`	`205 205`		`Substrate (By similarity).`
`MOD_RES`	`132 132`		`Phosphoserine (By similarity).`

Sequence information

Length: 245 AA [This is the length of the unprocessed precursor]

Molecular weight: 26662 Da [This is the MW of the unprocessed precursor]

CRC64: A846933ACBA6F83C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGRLDGKVIV LTAAAQGIGR AAALAFAKEG AKVIATDIND SKLQELDKYP GIHTRVLDVT 

        70         80         90        100        110        120 
KKKQIDQFAN DIERLDVLFN VAGFVHHGTI LDCEETDWDF SMNLNVRSMY LMIKAFLPKM 

       130        140        150        160        170        180 
MAQKSGNIIN MSSVASSIKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV 

       190        200        210        220        230        240 
DTPSLQERIQ ARPNPEEALS DFLKRQKTGR FATAEEVALL CVYLASDESA YITGNPVIID 


GGWSL

Q3T046 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools