[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1186/1471-2164-6-166; PubMed=16305752 [NCBI, ExPASy, EBI, Israel, Japan] Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.; "Characterization of 954 bovine full-CDS cDNA sequences."; BMC Genomics 6:166-166(2005).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Crossbred X Angus; TISSUE=Liver; NIH - Mammalian Gene Collection (MGC) project; Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-cysteine + O₂ = 3-sulfinoalanine.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2 .
SUBUNIT: Monomer (By similarity).
PTM: The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the ferrous ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen (By similarity).
SIMILARITY: Belongs to the cysteine dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BT025474; ABF57430.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC102709; AAI02710.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001029637.1; -.

UniGene

Bt.2723

3D structure databases

ModBase

Q3SZU4.

Family and domain databases

InterPro

IPR010300; Cys_dOase_I.
Graphical view of domain structure.

Pfam

PF05995; CDO_I; 1.
Pfam graphical view of domain structure.

BLOCKS

Q3SZU4.

Genome annotation databases

Ensembl

ENSBTAG00000017442; Bos taurus. [Contig view]

GeneID

514462; -.

KEGG

bta:514462; -.

Phylogenomic databases

HOVERGEN

Q3SZU4; -.

Other

ProtoNet

Q3SZU4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phosphoprotein; Thioether bond.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 200`	`200`	`Cysteine dioxygenase type 1.`	`PRO_0000246081`
`METAL`	`86 86`		`Iron (catalytic) (By similarity).`
`METAL`	`88 88`		`Iron (catalytic) (By similarity).`
`METAL`	`140 140`		`Iron (catalytic) (By similarity).`
`MOD_RES`	`59 59`		`Phosphothreonine (By similarity).`
`CROSSLNK`	`93 157`		`3'-(S-cysteinyl)-tyrosine (Cys-Tyr) (By similarity).`

Sequence information

Length: 200 AA [This is the length of the unprocessed precursor]

Molecular weight: 23013 Da [This is the MW of the unprocessed precursor]

CRC64: 65796B06507CF936 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MERTEVLKPR TLADLIRVLH QLFAGEEINV EEVQAVMEAY ESNPAEWAVY AKFDQYRYTR 

        70         80         90        100        110        120 
NLVDQGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKMLQG NLKETLFAWP DKKSNEMIKK 

       130        140        150        160        170        180 
SERILRENQC AYINDSIGLH RVENISHTEP AVSLHLYSPP FDTCHAFDQR TGHKNKVIMT 

       190        200 
FHSKFGIKTP FTTSGSLENN

Q3SZU4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools