ID   SSDH_HYLLA              Reviewed;         535 AA.
AC   Q3MSM3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   22-JUL-2008, entry version 22.
DE   RecName: Full=Succinate-semialdehyde dehydrogenase, mitochondrial;
DE            EC=1.2.1.24;
DE   AltName: Full=NAD(+)-dependent succinic semialdehyde dehydrogenase;
DE   AltName: Full=Aldehyde dehydrogenase family 5 member A1;
DE   Flags: Precursor;
GN   Name=ALDH5A1;
OS   Hylobates lar (Common gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Hylobates.
OX   NCBI_TaxID=9580;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Blasi P., Palmerio F., Aiello A., Rocchi M., Malaspina P.,
RA   Novelletto A.;
RT   "Human succinic semialdehyde dehydrogenase variation in higher
RT   primates: intra and inter specific data.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Succinate semialdehyde + NAD(+) + H(2)O =
CC       succinate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AJ891038; CAI69938.1; -; mRNA.
DR   HOVERGEN; Q3MSM3; -.
DR   GO; GO:0005625; C:soluble fraction; ISS:UniProtKB.
DR   GO; GO:0004777; F:succinate-semialdehyde dehydrogenase activity; ISS:UniProtKB.
DR   GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR   GO; GO:0009450; P:gamma-aminobutyric acid catabolic process; ISS:UniProtKB.
DR   GO; GO:0055114; P:oxidation reduction; ISS:UniProtKB.
DR   GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR010102; Succ_semiAld_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01780; SSADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; NAD; Oxidoreductase; Transit peptide.
FT   TRANSIT       1     47       Mitochondrion (Potential).
FT   CHAIN        48    535       Succinate-semialdehyde dehydrogenase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000042903.
FT   NP_BIND     284    289       NADP (By similarity).
FT   ACT_SITE    306    306       Proton acceptor (By similarity).
FT   ACT_SITE    340    340       Nucleophile (By similarity).
FT   SITE        205    205       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   535 AA;  57112 MW;  1D55DC672C6787B8 CRC64;
     MATCFWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGG LAGLSAALLR
     TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC SWREVSAKER
     SSLLRKWYNL MIQNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIY
     TPAKDRRALV LKQPIGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL
     AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV
     KRVSMELGGL APFIVFDSAN VDQAVAGALA SKFRNTGQTC VCSNRFLVQR GIHDAFVKAF
     AEAMKKNLHV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATIVTGG KRHQLGKNFF
     EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD TEEEAIAIAN AADVGLAGYF YSQDPAQIWR
     VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL
//