NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
"Complete sequence of Anabaena variabilis ATCC 29413.";
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: (S)-dihydroorotate + O₂ = orotate + H₂O₂.
COFACTOR: Binds 1 FMN per subunit (By similarity).
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6 .
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity).
SIMILARITY: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000117; ABA20846.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_321741.1; -.

3D structure databases

ModBase

Q3MDU0.

Enzyme and pathway databases

BioCyc

AVAR240292:AVA_1222-MON; -.

Ontologies

GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from HAMAP).
GO:0004158;	Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00225; -; 1.
PBIL [Tree]

InterPro

IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005719; DHO_DHase_2.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000164; DHO_oxidase; 1.

TIGRFAMs

TIGR01036; pyrD_sub2; 1.

PROSITE

PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.

BLOCKS

Q3MDU0.

Genome annotation databases

GeneID

3683262; -.

GenomeReviews

CP000117_GR; Ava_1222.

KEGG

ava:Ava_1222; -.

NMPDR

fig|240292.3.peg.1906; -.

Phylogenomic databases

HOGENOM

Q3MDU0; -.

Genome annotation databases

CMR

Q3MDU0; Ava_1222.

Other

ProtoNet

Q3MDU0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Complete proteome; Flavoprotein; FMN; Membrane; Oxidoreductase; Pyrimidine biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 376`	`376`	`Dihydroorotate dehydrogenase.`	`PRO_1000024151`
`ACT_SITE`	`193 193`		`Nucleophile (By similarity).`

Sequence information

Length: 376 AA [This is the length of the unprocessed precursor]

Molecular weight: 41318 Da [This is the MW of the unprocessed precursor]

CRC64: 0C58CDA5D2A728E8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDIYKFAVRP LLFDLVKADP EWLHQQTMRS LSWLSHTSDR TSTKWVQNIL QKSLCIEDSR 

        70         80         90        100        110        120 
LEQNLFGLRF PNPVGLAAGF DKDGVAARIW SSLGFGFAEL GTVTFVAQPG NPPPRLFRLP 

       130        140        150        160        170        180 
LDQAALNRMG FNNHGAAVMA TRLADEKGLF SIPIGINLGK SKVTPLEAAA EDYLNSFRLL 

       190        200        210        220        230        240 
KELGDYFVVN VSSPNTPGLR SLQDASMLSS ILDVLQKENQ SHKPIFVKIA PDLEWEAIAD 

       250        260        270        280        290        300 
IIGLAKTYQL AGIIATNTTI RRDGLKTQVI EQTGKAPQEE AGGISGAPVR DRSTEIIRFI 

       310        320        330        340        350        360 
WQQTQGEIPI IGVGGIFTPE DAWAKITAGA SLIQVYTGWI YQGPMMVSQI LTGLLAKLEE 

       370 
HELNSISEAI GLEFKS

Q3MDU0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools