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UniProtKB/Swiss-Prot entry Q3M5D3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX2_ANAVT
Primary accession number Q3M5D3
Secondary accession numbers None
Integrated into Swiss-Prot on April 4, 2006
Sequence was last modified on October 25, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 21)
Name and origin of the protein
Protein name Histidinol dehydrogenase 2
Synonyms HDH 2
EC 1.1.1.23
Gene name
Name: hisD2
OrderedLocusNames: Ava_4204
From
Anabaena variabilis (strain ATCC 29413 / PCC 7937) [TaxID: 240292] [HAMAP proteome]
Taxonomy Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
"Complete sequence of Anabaena variabilis ATCC 29413.";
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000117; ABA23803.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_324698.1; -.
3D structure databases
ModBase Q3M5D3.
Enzyme and pathway databases
BioCyc AVAR240292:AVA_4204-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q3M5D3.
Genome annotation databases
GeneID 3680948; -.
GenomeReviews CP000117_GR; Ava_4204.
KEGG ava:Ava_4204; -.
NMPDR fig|240292.3.peg.4200; -.
Phylogenomic databases
HOGENOM Q3M5D3; -.
Genome annotation databases
CMR Q3M5D3; Ava_4204.
Other
ProtoNet Q3M5D3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   433  433     Histidinol dehydrogenase 2. PRO_0000229849
ACT_SITE   328   328        Proton acceptor (By similarity). 
ACT_SITE   329   329        Proton acceptor (By similarity). 
METAL   260   260        Zinc (By similarity). 
METAL   263   263        Zinc (By similarity). 
METAL   362   362        Zinc (By similarity). 
METAL   421   421        Zinc (By similarity). 
BINDING   130   130        NAD (By similarity). 
BINDING   192   192        NAD (By similarity). 
BINDING   215   215        NAD (By similarity). 
BINDING   238   238        Substrate (By similarity). 
BINDING   260   260        Substrate (By similarity). 
BINDING   263   263        Substrate (By similarity). 
BINDING   329   329        Substrate (By similarity). 
BINDING   362   362        Substrate (By similarity). 
BINDING   416   416        Substrate (By similarity). 
BINDING   421   421        Substrate (By similarity). 
Sequence information
Length: 433 AA [This is the length of the unprocessed precursor] Molecular weight: 46701 Da [This is the MW of the unprocessed precursor] CRC64: 5C294698068A3ABA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLRIITQQAD VKAELQRICD RTHDEQVLHK EATVREVLQA VKRQGDKAVL HYTDEFDNQI 

        70         80         90        100        110        120 
LKAEELRVTG SELDAAYQQV SKELLEAIQL ASRQIEAFHR QRVPKSWVHF GDDDIVLGKR 

       130        140        150        160        170        180 
YTPVDRAGLY VPGGRAAYVS TVLMNAIPAK VAGVPRIVMA TPPGAQKAIN PAVLVAAQEV 

       190        200        210        220        230        240 
GVQEIYRVGG AQAIAALAYG TETIPKVDVI TGPGNIYVTL AKKLVYGTVG IDSLAGPSEV 

       250        260        270        280        290        300 
LIIADEGANP VHVATDMLAQ AEHDPMAAAI LFTTDPALAK NVQVAVERQL VDHPRRIDTE 

       310        320        330        340        350        360 
KAIAHYGLIV LVESLDAAAE LSNEFAPEHL ELEVKDPWAV LPNIRHAGAI FLGYSTPEAV 

       370        380        390        400        410        420 
GDYLAGPNHT LPTSGAARYA SALSVETFLK HSSIIQYSQT ALNKVAGAID ALATAEGLPS 

       430 
HADSVKRRIQ QDE
Q3M5D3 in FASTA format

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