NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine (By similarity).
CATALYTIC ACTIVITY: L-histidinol + 2 NAD⁺ = L-histidine + 2 NADH.
PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9 .
SIMILARITY: Belongs to the histidinol dehydrogenase family.
CAUTION: Could lack activity as the potential substrate and zinc-binding sites are missing.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000143; ABA78308.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_352209.1; -.

3D structure databases

ModBase

Q3J4H6.

Enzyme and pathway databases

BioCyc

RSPH272943:RSP_2155-MON; -.

Ontologies

GO:0004399;	Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105;	Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01024; atypical; 1.
PBIL [Tree]

InterPro

IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.

PANTHER

PTHR21256:SF2; Hstdl_DH_prok; 1.

Pfam

PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.

PRINTS

PR00083; HOLDHDRGNASE.

ProDom

PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00069; hisD; 1.

PROSITE

PS00611; HISOL_DEHYDROGENASE; 1.

BLOCKS

Q3J4H6.

Genome annotation databases

GeneID

3719625; -.

GenomeReviews

CP000143_GR; RHOS4_07400.

KEGG

rsp:RSP_2155; -.

NMPDR

fig|272943.3.peg.1346; -.

Phylogenomic databases

HOGENOM

Q3J4H6; -.

Genome annotation databases

CMR

Q3J4H6; RHOS4_07400.

Other

ProtoNet

Q3J4H6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 441`	`441`	`Putative histidinol dehydrogenase 2.`	`PRO_0000229864`
`ACT_SITE`	`334 334`		`Proton acceptor (By similarity).`
`ACT_SITE`	`335 335`		`Proton acceptor (By similarity).`

Sequence information

Length: 441 AA [This is the length of the unprocessed precursor]

Molecular weight: 46882 Da [This is the MW of the unprocessed precursor]

CRC64: B1481F195AAEA18E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVQVNFQVLA ELDAAGRAAL LRRSETDLSM FLEKVGPILE AVRTEGDAAL VRFGRELDRA 

        70         80         90        100        110        120 
EGLTREGLKV TEAEFDEAFG LVEPEIVAAI RFAIGNIRTF HEEQAPEPMW LKELRPGAFA 

       130        140        150        160        170        180 
GDRFTPIRSV ALYVPRGKGS FPSVTMMTSV PAVVAKVPQI AIFTPPAPDG RVDAATLVAA 

       190        200        210        220        230        240 
RLAGVETVYK VGGAQAVAAA AYGTETVTPA LKIVGPGSPW VVAAKRLLAG VIDPGLPAGP 

       250        260        270        280        290        300 
SESIILADET VHGGLAALDL LIEAEHGPDS SAWLVTHSRQ VAEEALAALP GHWSAMTPQR 

       310        320        330        340        350        360 
VDFSQAVLCG RAGGIVLTGS AEESHAFVND YAPEHLQILS EKPFEHLGRI TEAAEVLMGP 

       370        380        390        400        410        420 
HTPITIANFC LGPNAVLPTS RGARTWGPLS VHDFLRRSSV GYVTAPAYPE LAEVAKRLAE 

       430        440 
YEGFSSHANA VGPMRDAYLK R

Q3J4H6 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools