ID   BETA_XANC5              Reviewed;         556 AA.
AC   Q3BXK8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   04-NOV-2008, entry version 25.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=XCV0774;
OS   Xanthomonas campestris pv. vesicatoria (strain 85-10).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=316273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16237009; DOI=10.1128/JB.187.21.7254-7266.2005;
RA   Thieme F., Koebnik R., Bekel T., Berger C., Boch J., Buettner D.,
RA   Caldana C., Gaigalat L., Goesmann A., Kay S., Kirchner O., Lanz C.,
RA   Linke B., McHardy A.C., Meyer F., Mittenhuber G., Nies D.H.,
RA   Niesbach-Kloesgen U., Patschkowski T., Rueckert C., Rupp O.,
RA   Schneiker S., Schuster S.C., Vorhoelter F.J., Weber E., Puehler A.,
RA   Bonas U., Bartels D., Kaiser O.;
RT   "Insights into genome plasticity and pathogenicity of the plant
RT   pathogenic Bacterium Xanthomonas campestris pv. vesicatoria revealed
RT   by the complete genome sequence.";
RL   J. Bacteriol. 187:7254-7266(2005).
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AM039952; CAJ22405.1; -; Genomic_DNA.
DR   RefSeq; YP_362505.1; -.
DR   GeneID; 3729799; -.
DR   GenomeReviews; AM039952_GR; XCV0774.
DR   KEGG; xcv:XCV0774; -.
DR   NMPDR; fig|316273.3.peg.1262; -.
DR   HOGENOM; Q3BXK8; -.
DR   BioCyc; XCAM316273:XCV0774-MON; -.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    556       Choline dehydrogenase.
FT                                /FTId=PRO_0000258938.
FT   NP_BIND       6     35       FAD (Probable).
FT   ACT_SITE    475    475       By similarity.
SQ   SEQUENCE   556 AA;  61437 MW;  0950ACBCC7F4392A CRC64;
     MQREYDYIII GAGSAGNVLA ARLTEDPGVT VLLLEAGGPD YRLDFRTQMP AALAFPLQGR
     RYNWAYETEP EPYMDNRRME CGRGKGLGGS SLINGMCYIR GNALDFDHWA KRPGLEDWSY
     RDVLPYFRKA ETRDIGANDY HGGDGPVSVA TPKNDNNVLF HAMVEAGVQA GYPRTDDLNG
     YQQEGFGPMD RTVTPRGRRA STARGYLDMA KPRDGLHIVT HATTDRILFA GKRAIGVHYL
     VGNSSEGIDA HARREVLVCA GAIASPQLLQ RSGVGAPDLL RALDVQLVHD LPGVGQNLQD
     HLEVYIQYAC TKPVSLYPAL QWWNQPAIGA EWLFAGTGTG ASNQFEAGGF IRTREEFDWP
     NIQYHFLPVA INYNGSNAVK EHGFQAHVGS MRTPSRGRVH AKSRDPRQHP SILFNYQSTD
     QDWQEFRDAI RITREIIAQP ALDPYRGREI SPSADCKTDA ELDAFVRSRA ETAYHPSCSC
     AMGTDDMAVV DGQGRVHGME GLRVIDASIM PRIITGNLNA TTIMIAEKIA DRMRGRPPLP
     RSTADYYIAG DAPVRG
//