NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.;
"Complete sequence of Chlorobium chlorochromatii CaD3.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate + NADP⁺ = L-glutamyl 5-phosphate + NADPH.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the gamma-glutamyl phosphate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000108; ABB28364.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_379407.1; -.

3D structure databases

ModBase

Q3ARL1.

Enzyme and pathway databases

BioCyc

CCHL340177:CAG_1102-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350;	Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00412; -; 1.
PBIL [Tree]

InterPro

IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11063:SF1; GSA_DH; 1.

PIRSF000151; GPR; 1.

TIGR00407; proA; 1.

PS01223; PROA; 1.

Genome annotation databases

GeneID

3748320; -.

GenomeReviews

CP000108_GR; Cag_1102.

KEGG

cch:Cag_1102; -.

Phylogenomic databases

HOGENOM

Q3ARL1; -.

Genome annotation databases

CMR

Q3ARL1; Cag_1102.

Other

ProtoNet

Q3ARL1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 418`	`418`		`Gamma-glutamyl phosphate reductase.`	`PRO_0000229997`

Sequence information

Length: 418 AA [This is the length of the unprocessed precursor]

Molecular weight: 45897 Da [This is the MW of the unprocessed precursor]

CRC64: 087F32720C5FFEA0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKDQIIQKLH DVVRASRELV TLSDEAINRL LLDLADQIPN HQTAILEANQ RDIERMDSAN 

        70         80         90        100        110        120 
PMVDRLLLNE ARLQAIAADI RNVASLPTPL DAVLEKRTLP NGLELKKVSV PMGVIGIIYE 

       130        140        150        160        170        180 
ARPNVTFDVF ALCLKSGNAT VLKGGSDAMY SNIAIVELIH SVLQQHGINP DTLYLLPAER 

       190        200        210        220        230        240 
EAAAVMLGAV GYIDMIIPRG SQKLIDFVRD NSRVPVIETG AGIVHTYFDV SGDLELGKQV 

       250        260        270        280        290        300 
IFNAKTRRPS VCNALDTLVI HRDRLGDLSY LVEPLQSRQV ELFVDDAAYQ ELHGFYPKAL 

       310        320        330        340        350        360 
LHQAKPEHFG TEFLSLKMSV KTVANLDEAL EHIATYSSRH SEAIIATDAA TVATFMKRVD 

       370        380        390        400        410 
AAVVYANTST AFTDGAQFGL GAEIGISTQK LHARGPMALR EMTTYKWLIV GNGQVRPA

Q3ARL1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools