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UniProtKB/Swiss-Prot entry Q3AD53

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_CARHZ
Primary accession number Q3AD53
Secondary accession numbers None
Integrated into Swiss-Prot on April 4, 2006
Sequence was last modified on November 22, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 20)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: CHY_1085
From
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [TaxID: 246194] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales; Thermoanaerobacteraceae; Carboxydothermus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pgen.0010065; PubMed=16311624 [NCBI, ExPASy, EBI, Israel, Japan]
Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.;
"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901.";
PLoS Genet. 1:563-574(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000141; ABB15954.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_359931.1; -.
3D structure databases
ModBase Q3AD53.
Enzyme and pathway databases
BioCyc CHYD246194:CHY_1085-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q3AD53.
Genome annotation databases
GeneID 3728065; -.
GenomeReviews CP000141_GR; CHY_1085.
KEGG chy:CHY_1085; -.
NMPDR fig|246194.3.peg.1132; -.
TIGR CHY_1085; -.
Phylogenomic databases
HOGENOM Q3AD53; -.
Other
ProtoNet Q3AD53.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Histidinol dehydrogenase. PRO_0000229854
ACT_SITE   321   321        Proton acceptor (By similarity). 
ACT_SITE   322   322        Proton acceptor (By similarity). 
METAL   253   253        Zinc (By similarity). 
METAL   256   256        Zinc (By similarity). 
METAL   355   355        Zinc (By similarity). 
METAL   414   414        Zinc (By similarity). 
BINDING   231   231        Substrate (By similarity). 
BINDING   253   253        Substrate (By similarity). 
BINDING   256   256        Substrate (By similarity). 
BINDING   322   322        Substrate (By similarity). 
BINDING   355   355        Substrate (By similarity). 
BINDING   409   409        Substrate (By similarity). 
BINDING   414   414        Substrate (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 46608 Da [This is the MW of the unprocessed precursor] CRC64: 7E7C1B94C7FE042C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKLILNKEEL LDKYSRRKAV EEDIEQQVRK ILNEVASSGD EALIEYAREF DGFKGDLSNL 

        70         80         90        100        110        120 
KVSEEEIDKA YREVDDGFLN SLRKAIQRVF DFHQKQLPRS WFTTEENGNI LGQIYTPVEV 

       130        140        150        160        170        180 
AGIYVPGGTA AYPSSVVMNA VPAKVAGVKR IVMVSPQKGE RMNPYVLVAA REAGVTEIYR 

       190        200        210        220        230        240 
VGGAHAIAAL AFGTKTIPRV DVITGPGNIY VTIAKKLVYG TVNIDMLAGP SEVVVIADSS 

       250        260        270        280        290        300 
AKPEYLAADM LSQAEHDSLA SGVVITWDGE LARKTAQKVE EYLKLLPRRE IILKALENCG 

       310        320        330        340        350        360 
GIVVVDDEEE ALQLANQLAP EHLELMLPNP FGYLAKVKNA GAVFLGQFSP EPMGDYLAGP 

       370        380        390        400        410        420 
NHVLPTSGTS RFYSPLSVDN FLKKSSVIYY SQEGFLADAR DVIKLAETEG LFAHALSVKV 


RISNE
Q3AD53 in FASTA format

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