ID   3HAO_BURS3              Reviewed;         174 AA.
AC   Q39LI1;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   04-NOV-2008, entry version 30.
DE   RecName: Full=3-hydroxyanthranilate 3,4-dioxygenase;
DE            EC=1.13.11.6;
DE   AltName: Full=3-hydroxyanthranilic acid dioxygenase;
DE            Short=HAD;
DE   AltName: Full=3-hydroxyanthranilate oxygenase;
DE            Short=3-HAO;
GN   OrderedLocusNames=Bcep18194_C7641;
OS   Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760
OS   / NCIB 9086 / R18194)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=269483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 3 of Burkholderia sp. 383.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the oxidative ring opening of 3-
CC       hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde,
CC       which spontaneously cyclizes to quinolinate (By similarity).
CC   -!- CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O(2) = 2-amino-3-
CC       carboxymuconate semialdehyde.
CC   -!- COFACTOR: Binds 2 Fe(2+) ions per subunit (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the 3-HAO family.
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DR   EMBL; CP000150; ABB06685.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_367329.1; -.
DR   SMR; Q39LI1; 1-173.
DR   GeneID; 3734508; -.
DR   GenomeReviews; CP000150_GR; Bcep18194_C7641.
DR   KEGG; bur:Bcep18194_C7641; -.
DR   NMPDR; fig|269483.3.peg.4346; -.
DR   HOGENOM; Q39LI1; -.
DR   BioCyc; BSP36773:BCEP18194_C7641-MON; -.
DR   GO; GO:0000334; F:3-hydroxyanthranilate 3,4-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0008198; F:ferrous iron binding; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00825; -; 1.
DR   InterPro; IPR010329; 3hydroanth_dOase.
DR   Pfam; PF06052; 3-HAO; 1.
DR   TIGRFAMs; TIGR03037; anthran_nbaC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase.
FT   CHAIN         1    174       3-hydroxyanthranilate 3,4-dioxygenase.
FT                                /FTId=PRO_0000245474.
FT   METAL        51     51       Iron 1; catalytic (By similarity).
FT   METAL        57     57       Iron 1; catalytic (By similarity).
FT   METAL        95     95       Iron 1; catalytic (By similarity).
FT   METAL       125    125       Iron 2 (By similarity).
FT   METAL       128    128       Iron 2 (By similarity).
FT   METAL       162    162       Iron 2 (By similarity).
FT   METAL       165    165       Iron 2 (By similarity).
FT   BINDING      47     47       Dioxygen (By similarity).
FT   BINDING      57     57       Substrate (By similarity).
FT   BINDING      99     99       Substrate (By similarity).
FT   BINDING     110    110       Substrate (By similarity).
SQ   SEQUENCE   174 AA;  20048 MW;  FB19D9C29561A99B CRC64;
     MLKYGTPFNF SRWIDEHAHL LKPPVGNQQV WQDSDFIVTV VGGPNHRTDY HDDPFEEFFY
     QLRGNAYLHL WIDGKRERVD LKEGDMFLLP PHVRHSPQRP EAGSACLVIE RQRPAGVVDG
     FEWYCDACGH LVHRVEVQLK SIVDDLPPLF DAFYASDTLR RCAHCGHMHP GKAT
//