NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.;
"Complete sequence of chromosome 3 of Burkholderia sp. 383.";
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity).
CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O₂ = 2-amino-3-carboxymuconate semialdehyde.
COFACTOR: Binds 2 Fe(2+) ions per subunit (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the 3-HAO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000150; ABB06685.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_367329.1; -.

3D structure databases

SMR

Q39LI1; 1-173.

ModBase

Q39LI1.

Enzyme and pathway databases

BioCyc

BSP36773:BCEP18194_C7641-MON; -.

Ontologies

GO:0000334;	Molecular function: 3-hydroxyanthranilate 3,4-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0008198;	Molecular function: ferrous iron binding (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00825; -; 1.
PBIL [Tree]

InterPro

IPR010329; 3hydroanth_dOase.
Graphical view of domain structure.

Pfam

PF06052; 3-HAO; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR03037; anthran_nbaC; 1.

BLOCKS

Q39LI1.

Genome annotation databases

GeneID

3734508; -.

GenomeReviews

CP000150_GR; Bcep18194_C7641.

KEGG

bur:Bcep18194_C7641; -.

NMPDR

fig|269483.3.peg.4346; -.

Phylogenomic databases

HOGENOM

Q39LI1; -.

Genome annotation databases

CMR

Q39LI1; Bcep18194_C7641.

Other

ProtoNet

Q39LI1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 174`	`174`	`3-hydroxyanthranilate 3,4-dioxygenase.`	`PRO_0000245474`
`METAL`	`51 51`		`Iron 1; catalytic (By similarity).`
`METAL`	`57 57`		`Iron 1; catalytic (By similarity).`
`METAL`	`95 95`		`Iron 1; catalytic (By similarity).`
`METAL`	`125 125`		`Iron 2 (By similarity).`
`METAL`	`128 128`		`Iron 2 (By similarity).`
`METAL`	`162 162`		`Iron 2 (By similarity).`
`METAL`	`165 165`		`Iron 2 (By similarity).`
`BINDING`	`47 47`		`Dioxygen (By similarity).`
`BINDING`	`57 57`		`Substrate (By similarity).`
`BINDING`	`99 99`		`Substrate (By similarity).`
`BINDING`	`110 110`		`Substrate (By similarity).`

Sequence information

Length: 174 AA [This is the length of the unprocessed precursor]

Molecular weight: 20048 Da [This is the MW of the unprocessed precursor]

CRC64: FB19D9C29561A99B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLKYGTPFNF SRWIDEHAHL LKPPVGNQQV WQDSDFIVTV VGGPNHRTDY HDDPFEEFFY 

        70         80         90        100        110        120 
QLRGNAYLHL WIDGKRERVD LKEGDMFLLP PHVRHSPQRP EAGSACLVIE RQRPAGVVDG 

       130        140        150        160        170 
FEWYCDACGH LVHRVEVQLK SIVDDLPPLF DAFYASDTLR RCAHCGHMHP GKAT

Q39LI1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools