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UniProtKB/Swiss-Prot entry Q39K91

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BURS3
Primary accession number Q39K91
Secondary accession numbers None
Integrated into Swiss-Prot on April 4, 2006
Sequence was last modified on November 22, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 21)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: Bcep18194_A3523
From
Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [TaxID: 269483] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.;
"Complete sequence of chromosome 1 of Burkholderia sp. 383.";
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000151; ABB07125.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_367769.1; -.
3D structure databases
ModBase Q39K91.
Enzyme and pathway databases
BioCyc BSP36773:BCEP18194_A3523-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
IPR002035; VWF_A.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
PR00453; VWFADOMAIN.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q39K91.
Genome annotation databases
GeneID 3748700; -.
GenomeReviews CP000151_GR; Bcep18194_A3523.
KEGG bur:Bcep18194_A3523; -.
NMPDR fig|269483.3.peg.4827; -.
Phylogenomic databases
HOGENOM Q39K91; -.
Genome annotation databases
CMR Q39K91; Bcep18194_A3523.
Other
ProtoNet Q39K91.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   438  438     Histidinol dehydrogenase. PRO_0000229853
ACT_SITE   335   335        Proton acceptor (By similarity). 
ACT_SITE   336   336        Proton acceptor (By similarity). 
METAL   267   267        Zinc (By similarity). 
METAL   270   270        Zinc (By similarity). 
METAL   369   369        Zinc (By similarity). 
METAL   428   428        Zinc (By similarity). 
BINDING   138   138        NAD (By similarity). 
BINDING   199   199        NAD (By similarity). 
BINDING   222   222        NAD (By similarity). 
BINDING   245   245        Substrate (By similarity). 
BINDING   267   267        Substrate (By similarity). 
BINDING   270   270        Substrate (By similarity). 
BINDING   336   336        Substrate (By similarity). 
BINDING   369   369        Substrate (By similarity). 
BINDING   423   423        Substrate (By similarity). 
BINDING   428   428        Substrate (By similarity). 
Sequence information
Length: 438 AA [This is the length of the unprocessed precursor] Molecular weight: 46414 Da [This is the MW of the unprocessed precursor] CRC64: 2CD2FBB3520628C3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSITIRKLDS TSAGFGAELR ALLAFEASED AAIEQSVAQI LADVKSRGDA AVLEYTNRFD 

        70         80         90        100        110        120 
RLSASSIAAL ELPQDALQTA LDSLAPKARA ALEAAAARVR AYHEKQKIEC GTHSWQYTES 

       130        140        150        160        170        180 
DGTVLGQKVT PLDRVGLYVP GGKAAYPSSV LMNAIPARVA GVGEIVMVVP TPDGVKNDLV 

       190        200        210        220        230        240 
LAAALLGGVD RVFTIGGAQA VGALAYGTAT VPAVDKICGP GNAYVASAKR RVFGTVGIDM 

       250        260        270        280        290        300 
IAGPSEILVL CDGTTDPNWV AMDLFSQAEH DELAQSILLC PDGAFLERVE KAIDELLPSM 

       310        320        330        340        350        360 
PRQDVIRASL EGRGALIKVR DMAEACRIAN DIAPEHLEIS ALEPQQWGQQ IRHAGAIFLG 

       370        380        390        400        410        420 
RYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFIKRSS LIEVSAEGAQ TLGEIASELA 

       430 
YGEGLQAHAK SAEFRMKH
Q39K91 in FASTA format

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