[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Fontaine J.-M., Rousvoal S., Delaroque N., Loiseaux-De Goer S.; "Characterisation of the cox3, nad7 and atp6 genes from the mitochondrial genome of the brown alga Pylaiella littoralis."; Plant Physiol. Biochem. 33:605-609(1995).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z48623; CAA88557.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S53054; S53054.

RefSeq

NP_150429.1; -.

3D structure databases

ModBase

Q37720.

Ontologies

GO:0008137;	Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01962; NuoD; 1.

PROSITE

PS00535; COMPLEX1_49K; 1.

BLOCKS

Q37720.

Genome annotation databases

GeneID

803753; -.

Other

ProtoNet

Q37720.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Electron transport; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 398`	`398`		`NADH-ubiquinone oxidoreductase 49 kDa subunit.`	`PRO_0000118592`

Sequence information

Length: 398 AA [This is the length of the unprocessed precursor]

Molecular weight: 45245 Da [This is the MW of the unprocessed precursor]

CRC64: D3C46D2B7CA33FF6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALKKKEFNK KLKHFTINFG PQHPAAHGVL RLILELNGEV VQRADPHIGL LHRGTEKLIE 

        70         80         90        100        110        120 
AKTYFQALPY FDRLDYVSMM CQEHTYALSV ENLLQVSIPR RAQFIRVLFA EITRILNHLL 

       130        140        150        160        170        180 
AVGCHAMDVG AMTPFLWAFE EREKLMEFYE RVSGARMHAS YFRPGGVSQD ISVGLVDDIF 

       190        200        210        220        230        240 
AFVAQFGQRL DEIEEMLTDN RIWQERLVDI GVVSAQEAID WGFSGVMLRG SGIRWDLRKN 

       250        260        270        280        290        300 
EPYEIYSDLN FQGVVGKTGD CYDRYLARVE EMRQSLSIIY QCLNKMPRGS VKIDDAKISP 

       310        320        330        340        350        360 
PSRSEVKQSM ESLIHHFKLY TEGVFVPAGE TYTATEAPKG EFGVYLVSKG SSRPYRCKIK 

       370        380        390 
APGFSHLQGL NFMACSHMLA DVVTIIGTQD IVFGEVDR

Q37720 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools