ID   NDUS2_ACACA             Reviewed;         401 AA.
AC   Q37384;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   04-NOV-2008, entry version 52.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit;
DE            EC=1.6.5.3;
DE            EC=1.6.99.3;
DE   AltName: Full=NADH dehydrogenase subunit 7;
GN   Name=NAD7;
OS   Acanthamoeba castellanii (Amoeba).
OG   Mitochondrion.
OC   Eukaryota; Amoebozoa; Centramoebida; Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=5755;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 30010 / Neff;
RX   MEDLINE=95147275; PubMed=7844823; DOI=10.1006/jmbi.1994.0043;
RA   Burger G., Plante I., Lonergan K.M., Gray M.W.;
RT   "The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba
RT   castellanii: complete sequence, gene content and genome
RT   organization.";
RL   J. Mol. Biol. 245:522-537(1995).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity). Component of the iron-sulfur (IP)
CC       fragment of the enzyme.
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- CATALYTIC ACTIVITY: NADH + acceptor = NAD(+) + reduced acceptor.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
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DR   EMBL; U12386; AAD11854.1; -; Genomic_DNA.
DR   PIR; S53862; S53862.
DR   RefSeq; NP_042561.1; -.
DR   GeneID; 1734056; -.
DR   GO; GO:0005746; C:mitochondrial respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
DR   InterPro; IPR010219; NADH_DH_1_dsu.
DR   InterPro; IPR001135; NADH_UbQ_OxRdtase_49kDa.
DR   Pfam; PF00346; Complex1_49kDa; 1.
DR   TIGRFAMs; TIGR01962; NuoD; 1.
DR   PROSITE; PS00535; COMPLEX1_49K; 1.
PE   3: Inferred from homology;
KW   Electron transport; Mitochondrion; NAD; Oxidoreductase;
KW   Respiratory chain; Transport; Ubiquinone.
FT   CHAIN         1    401       NADH-ubiquinone oxidoreductase 49 kDa
FT                                subunit.
FT                                /FTId=PRO_0000118587.
SQ   SEQUENCE   401 AA;  46096 MW;  BA929F88024C0DF8 CRC64;
     MRKNQISPYI KTSKIKNFTM NFGPQHPAAH GVLRLILELD GELVRKADPH IGLLHRGTEK
     LIEYKTYIQA LPYFDRLDYV SMMSQEHAYS LAIEKLLNCN VPIRAQYIRV IYSELTRILN
     HILAVTTHAM DVGALTPFLW LFEEREKLME FYERVSGARM HAAYIRPGGV AQDFPLGLWN
     DIMQFVEQFF WRLVEVEELL NGNRIWKQRL VDVGIVTAEE ALSHGFSGVM LRGSGIAWDL
     RKNNPYEVYN KLNFNIPIGK NGDCYDRYLI RVYEMYESLN IIKQCLTAMP AGLIKVNDKK
     ITPPERTDMK YSMESLIHHF KLYSEGFNVP ENETYACVEA PKGEFGVYVV SDGSNKPYRC
     KIKAPGFLHL QSLNSMSKGH MIADVVTIIG TQDIVFGEID R
//