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UniProtKB/Swiss-Prot entry Q2YL58

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_BRUA2
Primary accession number Q2YL58
Secondary accession numbers None
Integrated into Swiss-Prot on September 19, 2006
Sequence was last modified on February 7, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 21)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: BAB2_0346
From
Brucella abortus (strain 2308) [TaxID: 359391] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/IAI.73.12.8353-8361.2005; PubMed=16299333 [NCBI, ExPASy, EBI, Israel, Japan]
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
"Whole-genome analyses of speciation events in pathogenic Brucellae.";
Infect. Immun. 73:8353-8361(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AM040265; CAJ12512.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_418553.1; -.
3D structure databases
ModBase Q2YL58.
Enzyme and pathway databases
BioCyc BMEL359391:BAB2_0346-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q2YL58.
Genome annotation databases
GeneID 3827559; -.
GenomeReviews AM040265_GR; BAB2_0346.
KEGG bmf:BAB2_0346; -.
Phylogenomic databases
HOGENOM Q2YL58; -.
Genome annotation databases
CMR Q2YL58; BAB2_0346.
Other
ProtoNet Q2YL58.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   370  370     3-isopropylmalate dehydrogenase. PRO_0000250106
NP_BIND   77    90  14     NAD (By similarity). 
NP_BIND   290   302  13     NAD (By similarity). 
METAL   226   226        Magnesium or manganese (By similarity). 
METAL   250   250        Magnesium or manganese (By similarity). 
METAL   254   254        Magnesium or manganese (By similarity). 
BINDING   97    97        Substrate (By similarity). 
BINDING   107   107        Substrate (By similarity). 
BINDING   135   135        Substrate (By similarity). 
BINDING   226   226        Substrate (By similarity). 
SITE   142   142  1     Important for catalysis (By similarity). 
SITE   193   193  1     Important for catalysis (By similarity). 
Sequence information
Length: 370 AA [This is the length of the unprocessed precursor] Molecular weight: 39730 Da [This is the MW of the unprocessed precursor] CRC64: 5A389C4E26E82DFF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MASRKLLLLP GDGIGPEAMA EVRKVIAFLN SDLNLGFETE EGLVGGCAYD AHGQAISDAD 

        70         80         90        100        110        120 
MEKALAADSV LFGAVGGPKW DSVPYEVRPE AGLLRLRKDM QLYANLRPAI CYPALAHSSS 

       130        140        150        160        170        180 
LKPEVIEGLD ILILRELTGG VYFGEPKEII DLGNGQKRGI DTQVYDTYEI ERIADVAFEL 

       190        200        210        220        230        240 
ARTRRNKVTS MEKRNVMKSG VLWNQGVTAR HKEKHADVQL EHMLADAGGM QLVRWPKQFD 

       250        260        270        280        290        300 
VILTDNLFGD LLSDVAAMLT GSLGMLPSAS LGAADSKTGK RKALYEPVHG SAPDIAGKGI 

       310        320        330        340        350        360 
ANPIAMIASL AMCLRYSFGL VAEADRLEAA IAGVLDDGIR TADIWSEGNT KVGTTEMGDA 

       370 
ILAKFKALSA
Q2YL58 in FASTA format

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