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UniProtKB/Swiss-Prot entry Q2XQV4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALDH2_PIG
Primary accession number Q2XQV4
Secondary accession numbers None
Integrated into Swiss-Prot on December 4, 2007
Sequence was last modified on December 20, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 23)
Name and origin of the protein
Protein name Aldehyde dehydrogenase, mitochondrial [Precursor]
Synonyms EC 1.2.1.3
ALDH class 2
ALDH-E2
Gene name
Name: ALDH2
From
Sus scrofa (Pig) [TaxID: 9823] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Ji Y., Bennett B.M.;
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
DQ266356; ABB70228.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001038076.1; -.
UniGene Ssc.11147
3D structure databases
SMR Q2XQV4; 28-521.
ModBase Q2XQV4.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q2XQV4.
Genome annotation databases
GeneID 733685; -.
KEGG ssc:733685; -.
Phylogenomic databases
HOVERGEN Q2XQV4; -.
Other
ProtoNet Q2XQV4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    21  21     Mitochondrion (By similarity). 
CHAIN   22   521  500     Aldehyde dehydrogenase, mitochondrial. PRO_0000312492
NP_BIND   266   271  6     NAD (By similarity). 
ACT_SITE   289   289        Proton acceptor (By similarity). 
ACT_SITE   323   323        Nucleophile (By similarity). 
SITE   190   190  1     Transition state stabilizer (By similarity). 
MOD_RES   22    22        N-acetylserine (By similarity). 
MOD_RES   372   372        N6-acetyllysine (By similarity). 
Sequence information
Length: 521 AA [This is the length of the unprocessed precursor] Molecular weight: 56921 Da [This is the MW of the unprocessed precursor] CRC64: 12913E10ECD560A7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLRPAALAAA RLVLRQGRRL LSAAPTQAVP APNQQPEIFY NQIFINNEWH DAISKKTFPT 

        70         80         90        100        110        120 
VNPSTGDVIC HVAEGDKEDV DRAVEAARAA FQLGSPWRRL DASDRGRLLN RLADLIERDR 

       130        140        150        160        170        180 
TYLAALETLD NGKPYVISYL VDLDMVLKCL RYYAGWADKY HGKTLPIDGD YFSYTRHEPV 

       190        200        210        220        230        240 
GVCGQIIPWN FPLLMQAWKL GPALATGNVV VMKVSEQTPL TALYVANLIK EAGFPPGVVN 

       250        260        270        280        290        300 
IVPGYGPTAG AAIASHEDVD KVAFTGSTEV GHLIQVAAGK SNLKRVTLEL GGKSPNIIMS 

       310        320        330        340        350        360 
DADMDWAVEQ AHFALFFNQG QCCCAGSRTF VQEDIYAEFV ERSVARARSR VVGNPFDSRT 

       370        380        390        400        410        420 
EQGPQIDETQ FKKILGYIKS GKEEGAKLLC GGGAAADRGY FIQPTVFGDV QDGMTIAKEE 

       430        440        450        460        470        480 
IFGPVMQILK FKTIEEVIGR ANNSKYGLAA AVFTKDLDKA NYLSQALQAG TVWVNCYDVF 

       490        500        510        520 
GAQSPFGGYK LSGSGRELGE YGLQAYTEVK TVTVKVPQKN S
Q2XQV4 in FASTA format

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