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UniProtKB/Swiss-Prot entry Q2T7H6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_BURTA
Primary accession number Q2T7H6
Secondary accession numbers None
Integrated into Swiss-Prot on September 19, 2006
Sequence was last modified on January 24, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 24)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: BTH_II0674
From
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [TaxID: 271848] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; pseudomallei group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000085; ABC35976.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_438873.1; -.
3D structure databases
ModBase Q2T7H6.
Enzyme and pathway databases
BioCyc BTHA271848:BTH_II0674-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q2T7H6.
Genome annotation databases
GeneID 3845853; -.
GenomeReviews CP000085_GR; BTH_II0674.
KEGG bte:BTH_II0674; -.
TIGR BTH_II0674; -.
Phylogenomic databases
HOGENOM Q2T7H6; -.
Other
ProtoNet Q2T7H6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   355  355     3-isopropylmalate dehydrogenase. PRO_0000250109
NP_BIND   280   292  13     NAD (By similarity). 
METAL   222   222        Magnesium or manganese (By similarity). 
METAL   246   246        Magnesium or manganese (By similarity). 
METAL   250   250        Magnesium or manganese (By similarity). 
BINDING   90    90        Substrate (By similarity). 
BINDING   100   100        Substrate (By similarity). 
BINDING   128   128        Substrate (By similarity). 
BINDING   222   222        Substrate (By similarity). 
SITE   135   135  1     Important for catalysis (By similarity). 
SITE   190   190  1     Important for catalysis (By similarity). 
Sequence information
Length: 355 AA [This is the length of the unprocessed precursor] Molecular weight: 38242 Da [This is the MW of the unprocessed precursor] CRC64: CE8C13AF0007C5E4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKIAVLPGDG IGPEIVNEAV KVLNALDEKF ELEHAPVGGA GYEASGHPLP DATLALAKEA 

        70         80         90        100        110        120 
DAILFGAVGD WKYDSLERAL RPEQAILGLR KHLELFANFR PAICYPQLVD ASPLKPELVA 

       130        140        150        160        170        180 
GLDILIVREL NGDIYFGQPR GVRAAPDGPF AGEREGFDTM RYSEPEVRRI AHVAFQAAQK 

       190        200        210        220        230        240 
RAKKLLSVDK SNVLETSQFW RDVMIDVSKE YADVELSHMY VDNAAMQLAK APKQFDVIVT 

       250        260        270        280        290        300 
GNMFGDILSD EASMLTGSIG MLPSASLDKN NKGLYEPSHG SAPDIAGKGI ANPLATILSA 

       310        320        330        340        350 
AMLLRYSLNR AEQADRIERA VKTVLEQGYR TGDIATPGCR QVGTAAMGDA VVAAL
Q2T7H6 in FASTA format

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