NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.4106106; PubMed=16365377 [NCBI, ExPASy, EBI, Israel, Japan]
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.;
"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
Genome Res. 16:149-156(2006).

Comments

CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD⁺ = D-fructose 6-phosphate + NADH.
SIMILARITY: Belongs to the mannitol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP008232; BAE73290.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_453695.1; -.

3D structure databases

ModBase

Q2NX35.

Enzyme and pathway databases

BioCyc

SGLO343509:SG0015-MON; -.

Ontologies

GO:0008926;	Molecular function: mannitol-1-phosphate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00196; -; 1.
PBIL [Tree]

InterPro

IPR013328; DHase_multihelical.
IPR013118; Mannitol_DHase_C.
IPR000669; Mannitol_DHase_core.
IPR013131; Mannitol_DHase_N.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.

Pfam

PF01232; Mannitol_dh; 1.
PF08125; Mannitol_dh_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00084; MTLDHDRGNASE.

PROSITE

PS00974; MANNITOL_DHGENASE; 1.

BLOCKS

Q2NX35.

Genome annotation databases

3867672; -.

AP008232_GR; SG0015.

sgl:SG0015; -.

fig|343509.6.peg.42; -.

Phylogenomic databases

HOGENOM

Q2NX35; -.

Genome annotation databases

CMR

Q2NX35; SG0015.

Other

ProtoNet

Q2NX35.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 382`	`382`	`Mannitol-1-phosphate 5-dehydrogenase.`	`PRO_1000011811`
`NP_BIND`	`3 14`	`12`	`NAD (By similarity).`

Sequence information

Length: 382 AA [This is the length of the unprocessed precursor]

Molecular weight: 41274 Da [This is the MW of the unprocessed precursor]

CRC64: 4226CEC89748BA18 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKVLHFGAGN IGRGFIGKLL ADAGVEVVFA DVNQQVLDAL NQRHQYQVRV VGEQAQVETV 

        70         80         90        100        110        120 
RGVSAVHSGS DDVVALIASV DLVTAAVGPQ ILERIAPAIA RGLVKRHDGG GTQPLNIIAC 

       130        140        150        160        170        180 
ENMVRGTSQL KQHVLNALEP RYHAWVDQHV GFVDSAVDRI VPPVEAGSDD PLAVTVESFS 

       190        200        210        220        230        240 
EWILDKTQFK GVPPALGGME LTDNLMAFME RKLFTLNTGH AITAYLGQLA GHQTIRDAIL 

       250        260        270        280        290        300 
DPAVRQTVKG AMEESGAVLI NRYGFDARKH AAYINKILQR FENPYLHDDV ERVGRQPLRK 

       310        320        330        340        350        360 
LGAGDRLIKP LRGTLEYGLG DANLVTGIAA AMHYHSDQDP QAKEWAALLA EVGPQAALAK 

       370        380 
VSGLEEDSEV VAQVVNAYNA MQ

Q2NX35 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools