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UniProtKB/Swiss-Prot entry Q2NUD3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_SODGM
Primary accession number Q2NUD3
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on February 7, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 25)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: SG0967
From
Sodalis glossinidius (strain morsitans) [TaxID: 343509] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Sodalis.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.4106106; PubMed=16365377 [NCBI, ExPASy, EBI, Israel, Japan]
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.;
"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
Genome Res. 16:149-156(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AP008232; BAE74242.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_454647.1; -.
3D structure databases
ModBase Q2NUD3.
Enzyme and pathway databases
BioCyc SGLO343509:SG0967-MON; -.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS Q2NUD3.
Genome annotation databases
GeneID 3867094; -.
GenomeReviews AP008232_GR; SG0967.
KEGG sgl:SG0967; -.
NMPDR fig|343509.6.peg.2010; -.
Phylogenomic databases
HOGENOM Q2NUD3; -.
Genome annotation databases
CMR Q2NUD3; SG0967.
Other
ProtoNet Q2NUD3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   565  565     NAD-dependent malic enzyme. PRO_1000069550
ACT_SITE   104   104        Proton donor (By similarity). 
ACT_SITE   175   175        Proton acceptor (By similarity). 
METAL   246   246        Divalent metal cation (By similarity). 
METAL   247   247        Divalent metal cation (By similarity). 
METAL   270   270        Divalent metal cation (By similarity). 
BINDING   157   157        NAD (By similarity). 
BINDING   270   270        NAD (By similarity). 
BINDING   418   418        NAD (By similarity). 
SITE   270   270  1     Important for activity (By similarity). 
Sequence information
Length: 565 AA [This is the length of the unprocessed precursor] Molecular weight: 62560 Da [This is the MW of the unprocessed precursor] CRC64: 54D4A810844D312E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MELEYESKRP LYIPHAGPIL LEFPLLNKGS AFSLEERDNF NLQGLLPDTV ETIEEQAERA 

        70         80         90        100        110        120 
WRQYQDFRTN IDRHIYLRNI QDTNETLFYR LLAAHLAEML PIIYTPTVGD ACERFSDIYR 

       130        140        150        160        170        180 
RARGVFISYN NCDKIEDMLQ NATKQNVKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
ACGGISPAYT LPVVLDAGTN NQQLLNDPLY MGWRHPRITG EQYDKFVDAF IQAVKRRWPN 

       250        260        270        280        290        300 
VLLQFEDFAQ KNATPLLNRY RSELCCFNDD IQGTAAVTLG CLLAASRAAG KRLRDQKVVF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQITAEMRT EGLSEDEARR RVLMVDRFGL LTDKLANLLD FQSRLVQPSD 

       370        380        390        400        410        420 
SLSDWQLDSD TISLQDVVRN ARPTVLIGVS GQPGLFTEEI IRDMHQHCER PIVMPLSNPT 

       430        440        450        460        470        480 
SRVEATPEDL LRWTDGAALV ATGSPFAPVQ FEGKTYPIAQ CNNAYIFPGI GLGVLASGAG 

       490        500        510        520        530        540 
QITDAMLIAA SRALADCSPL ANGDGGALLP DINDIQSVSR VIAMAVAKAA QVHGVALVTS 

       550        560 
EETLSLAIEH NFWQPQYRDY RRTSF
Q2NUD3 in FASTA format

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