[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Crossbred X Angus; TISSUE=Liver; NIH - Mammalian Gene Collection (MGC) project; Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: 2 glutathione + H₂O₂ = glutathione disulfide + 2 H₂O.
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the glutathione peroxidase family.

Copyright

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Cross-references

Sequence databases

EMBL

BC111287; AAI11288.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001039553.1; -.

UniGene

Bt.28466

3D structure databases

ModBase

Q2NL01.

Family and domain databases

InterPro

IPR013376; Glut_perox_Gpx7.
IPR000889; Glut_peroxidase.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.30.10; Thioredoxin_fold; 1.

PANTHER

PTHR11592; Glut_peroxidase; 1.

Pfam

PF00255; GSHPx; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000303; Glutathion_perox; 1.

PRINTS

PR01011; GLUTPROXDASE.

TIGRFAMs

TIGR02540; gpx7; 1.

PROSITE

PS00460; GLUTATHIONE_PEROXID_1; FALSE_NEG.
PS00763; GLUTATHIONE_PEROXID_2; 1.
PS51355; GLUTATHIONE_PEROXID_3; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q2NL01.

Genome annotation databases

Ensembl

ENSBTAG00000021960; Bos taurus. [Contig view]

GeneID

511575; -.

KEGG

bta:511575; -.

Phylogenomic databases

HOVERGEN

Q2NL01; -.

Other

ProtoNet

Q2NL01.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Membrane; Oxidoreductase; Peroxidase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 209`	`209`	`Probable glutathione peroxidase 8.`	`PRO_0000317755`
`TRANSMEM`	`18 40`	`23`	`Potential.`
`ACT_SITE`	`79 79`		`By similarity.`

Sequence information

Length: 209 AA [This is the length of the unprocessed precursor]

Molecular weight: 23983 Da [This is the MW of the unprocessed precursor]

CRC64: 3A26DF87DBA34B3B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEPLTAYPLR CSGPKAKAFA VLLSMVLCTV MLFLLQLKFL KPKINSFYTF EVKDANGRVV 

        70         80         90        100        110        120 
SLEKFKGKVA LVVNVASDCQ LTDRNYLALQ ELHKEFGPFH FSVLAFPCNQ FGESEPRPSK 

       130        140        150        160        170        180 
EVVSFARNNF GVTFPIFHKI KILGSEAEPA FRFLVDSSKK EPRWNFWKYL VNPEGQVVKT 

       190        200 
WRPEEPIEVI RPEIAALIRQ MIIKKKEDL

Q2NL01 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools