NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.01927-05; PubMed=16885469 [NCBI, ExPASy, EBI, Israel, Japan]
Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.;
"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction.";
J. Bacteriol. 188:6002-6015(2006).

Comments

CATALYTIC ACTIVITY: (S)-dihydroorotate + O₂ = orotate + H₂O₂.
COFACTOR: Binds 1 FMN per subunit (By similarity).
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6 .
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity).
SIMILARITY: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AM167904; CAJ50364.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_787251.1; -.

3D structure databases

ModBase

Q2KW44.

Ontologies

GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from HAMAP).
GO:0004158;	Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00225; -; 1.
PBIL [Tree]

InterPro

IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005719; DHO_DHase_2.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000164; DHO_oxidase; 1.

TIGRFAMs

TIGR01036; pyrD_sub2; 1.

PROSITE

PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.

BLOCKS

Q2KW44.

Genome annotation databases

GeneID

6266676; -.

GenomeReviews

AM167904_GR; BAV2753.

KEGG

bav:BAV2753; -.

NMPDR

fig|521.1.peg.356; -.

Phylogenomic databases

HOGENOM

Q2KW44; -.

Genome annotation databases

CMR

Q2KW44; BAV2753.

Other

ProtoNet

Q2KW44.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Complete proteome; Flavoprotein; FMN; Membrane; Oxidoreductase; Pyrimidine biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 349`	`349`	`Dihydroorotate dehydrogenase.`	`PRO_1000024154`
`ACT_SITE`	`183 183`		`Nucleophile (By similarity).`

Sequence information

Length: 349 AA [This is the length of the unprocessed precursor]

Molecular weight: 37027 Da [This is the MW of the unprocessed precursor]

CRC64: 2B79F6391D1BAF15 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSILFNAYPL ARPALFAMDA ETAHEVTLAS LQRAYDCGTT RRWLHDQPQL PTTLMGMTLR 

        70         80         90        100        110        120 
NPVGLAAGLD KNGAFIDALG NLGFGFVEVG TVTPRAQSGN PKPRMFRLPK ANALINRLGF 

       130        140        150        160        170        180 
NNQGLDAFLA NVTRSRFRSQ GGILGLNIGK NADTPIERAA DDYLIGLAGV YPHADYVTVN 

       190        200        210        220        230        240 
ISSPNTKNLR ALQGGDELSQ LLAALRDKRA ELAQQHARQV PLVVKIAPDL SQEQIDIIAD 

       250        260        270        280        290        300 
TLLSNGVDGV IATNTTLSRE AVQGMPHAAE TGGLSGAPVH ELSLAVIERL RQRVGSALAI 

       310        320        330        340 
IGVGGILSGQ QAREKIAAGA DAVQLYTGLI YRGPALVGEC VGTLKNTAR

Q2KW44 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools