[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Testis; NIH - Mammalian Gene Collection (MGC) project; Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
CATALYTIC ACTIVITY: L-tryptophan + O₂ = N-formyl-L-kynurenine.
COFACTOR: Binds 2 heme groups per tetramer. The hemes are protoheme IV (By similarity).
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2 .
SUBUNIT: Homotetramer (By similarity).
SIMILARITY: Belongs to the tryptophan 2,3-dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC112550; AAI12551.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001039778.1; -.

UniGene

Bt.55173

3D structure databases

ModBase

Q2KIQ5.

Family and domain databases

InterPro

IPR004981; Trp_2_3_dOase.
Graphical view of domain structure.

PANTHER

PTHR10138; Trp_2_3_dOase; 1.

Pfam

PF03301; Trp_dioxygenase; 1.
Pfam graphical view of domain structure.

BLOCKS

Q2KIQ5.

Genome annotation databases

Ensembl

ENSBTAG00000011062; Bos taurus. [Contig view]

GeneID

530397; -.

KEGG

bta:530397; -.

Phylogenomic databases

HOVERGEN

Q2KIQ5; -.

Other

ProtoNet

Q2KIQ5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Dioxygenase; Heme; Iron; Metal-binding; Oxidoreductase; Phosphoprotein.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 406`	`406`	`Tryptophan 2,3-dioxygenase.`	`PRO_0000247474`
`MOD_RES`	`19 19`		`Phosphoserine (By similarity).`
`MOD_RES`	`155 155`		`Phosphoserine (By similarity).`

Sequence information

Length: 406 AA [This is the length of the unprocessed precursor]

Molecular weight: 47708 Da [This is the MW of the unprocessed precursor]

CRC64: D68CD8A6BC59A882 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGCPFLGKS FGYAFKPLSA QGSEEDKSQA GVNRASKGGL IYGNYLQLEK VLNAQELQSE 

        70         80         90        100        110        120 
MKGNKIHDEH LFIITHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VITRMHRVVV 

       130        140        150        160        170        180 
ILKLLVQQFS VLETMTALDF NDFREYLSPA SGFQSLQFRL LENKIGVLQS LRVPYNRRHY 

       190        200        210        220        230        240 
RDNFRGKDNE LLLKSEQERT LLQLVEAWLE RTPGLEPHGF NFWGKLEKNI VKGLEEEFTK 

       250        260        270        280        290        300 
IQAKEESEEK EEQMAEFQKQ KEVLLSLFDE KRHEHLLSKG ERRLSYKALQ GALMIYFYRE 

       310        320        330        340        350        360 
EPRFQVPFQL LTFLMDVDSL MTKWRYNHVC LVHRMLGSKA GTGGSSGYQY LRSTVSDRYK 

       370        380        390        400 
VFVDLFNLST YLVPRHWIPK MNPVIHKFLY TAEYCDSSYF SSDESD

Q2KIQ5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools