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UniProtKB/Swiss-Prot entry Q2HZ26

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TPH2_MACMU
Primary accession number Q2HZ26
Secondary accession numbers None
Integrated into Swiss-Prot on October 3, 2006
Sequence was last modified on March 7, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 19)
Name and origin of the protein
Protein name Tryptophan 5-hydroxylase 2
Synonyms EC 1.14.16.4
Tryptophan 5-monooxygenase 2
Gene name
Name: TPH2
From
Macaca mulatta (Rhesus macaque) [TaxID: 9544] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Chen G.-L., Miller G.M.;
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
DQ360113; ABC94730.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001035035.1; -.
UniGene Mmu.10250
3D structure databases
SMR Q2HZ26; 151-439.
ModBase Q2HZ26.
Family and domain databases
InterPro IPR001273; Aaa_hydroxylase.
IPR005963; Tyr_5_mOase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
PANTHER PTHR11473; Aaa_hydroxylase; 1.
Pfam PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.
PRINTS PR00372; FYWHYDRXLASE.
ProDom PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01270; Trp_5_monoox; 1.
PROSITE PS00367; BIOPTERIN_HYDROXYL; 1.
BLOCKS Q2HZ26.
Genome annotation databases
Ensembl ENSMMUG00000007730; Macaca mulatta. [Contig view]
GeneID 664730; -.
KEGG mcc:664730; -.
Phylogenomic databases
HOVERGEN Q2HZ26; -.
Other
ProtoNet Q2HZ26.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phosphoprotein; Serotonin biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   490  490     Tryptophan 5-hydroxylase 2. PRO_0000252111
DOMAIN   64   136  73     ACT. 
METAL   318   318        Iron (By similarity). 
METAL   323   323        Iron (By similarity). 
METAL   363   363        Iron (By similarity). 
MOD_RES   382   382        Phosphoserine (By similarity). 
MOD_RES   392   392        Phosphoserine (By similarity). 
Sequence information
Length: 490 AA [This is the length of the unprocessed precursor] Molecular weight: 56095 Da [This is the MW of the unprocessed precursor] CRC64: DB6A60DD77B4D5AA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGNLTLNKAN SGKNDDKGNK GSSKNETATE 

        70         80         90        100        110        120 
SGKTAVVFSL KNEVGGLVKA LRLFQEKRVH MVHIESRKSR RRSSEVEIFV DCECGKTEFN 

       130        140        150        160        170        180 
ELIQLLKFQT TIVTLNPPEN IWTEEEELED VPWFPRKISE LDKCSHRVLM YGSELDADHP 

       190        200        210        220        230        240 
GFKDNVYRQR RKYFVDVAMG YKYGQPIPRV EYTEEETKTW GVVFRELSKL YPTHACREYL 

       250        260        270        280        290        300 
KNFPLLTKYC GYREDNVPQL EDVSMFLKER SGFTVRPVAG YLSPRDFLAG LAYRVFHCTQ 

       310        320        330        340        350        360 
YIRHGSDPLY TPEPDTCHEL LGHVPLLADP KFAQFSQEIG LASLGASDED VQKLATCYFF 

       370        380        390        400        410        420 
TIEFGLCKQE GQLRAYGAGL LSSIGELKHA LSDKACVKAF DPKTTCLQEC LITTFQEAYF 

       430        440        450        460        470        480 
VSESFEEAKE KMRDFAKSIT RPFSVYFNPY TQSIEILKDT RSIENVVQDL RSDLNTVCDA 

       490 
LNKMNQYLGI
Q2HZ26 in FASTA format

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