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UniProtKB/Swiss-Prot entry Q2FK29

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH1_STAA3
Primary accession number Q2FK29
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2006
Sequence was last modified on May 30, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 21)
Name and origin of the protein
Protein name L-lactate dehydrogenase 1
Synonyms L-LDH 1
EC 1.1.1.27
Gene name
Name: ldh1
OrderedLocusNames: SAUSA300_0235
From
Staphylococcus aureus (strain USA300) [TaxID: 367830] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(06)68231-7; PubMed=16517273 [NCBI, ExPASy, EBI, Israel, Japan]
Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.;
"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus.";
Lancet 367:731-739(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000255; ABD22054.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_492949.1; -.
3D structure databases
ModBase Q2FK29.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q2FK29.
Genome annotation databases
GeneID 3915181; -.
GenomeReviews CP000255_GR; SAUSA300_0235.
KEGG saa:SAUSA300_0235; -.
Phylogenomic databases
HOGENOM Q2FK29; -.
Genome annotation databases
CMR Q2FK29; SAUSA300_0235.
Other
ProtoNet Q2FK29.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein; Stress response.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   317  317     L-lactate dehydrogenase 1. PRO_0000237559
NP_BIND   15    45  31     NAD (By similarity). 
ACT_SITE   179   179        Proton acceptor (By similarity). 
BINDING   92    92        Substrate (By similarity). 
BINDING   124   124        NAD or substrate (By similarity). 
BINDING   155   155        Substrate (By similarity). 
BINDING   232   232        Substrate (By similarity). 
MOD_RES   223   223        Phosphotyrosine (By similarity). 
Sequence information
Length: 317 AA [This is the length of the unprocessed precursor] Molecular weight: 34583 Da [This is the MW of the unprocessed precursor] CRC64: CDDE481269B7DE56 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNKFKGNKVV LIGNGAVGSS YAFSLVNQSI VDELVIIDLD TEKVRGDVMD LKHATPYSPT 

        70         80         90        100        110        120 
TVRVKAGEYS DCHDADLVVI CAGAAQKPGE TRLDLVSKNL KIFKSIVGEV MASKFDGIFL 

       130        140        150        160        170        180 
VATNPVDILA YATWKFSGLP KERVIGSGTI LDSARFRLLL SEAFDVAPRS VDAQIIGEHG 

       190        200        210        220        230        240 
DTELPVWSHA NIAGQPLKTL LEQRPEGKAQ IEQIFVQTRD AAYDIIQAKG ATYYGVAMGL 

       250        260        270        280        290        300 
ARITEAIFRN EDAVLTVSAL LEGEYEEEDV YIGVPAVINR NGIRNVVEIP LNDEEQSKFA 

       310 
HSAKTLKDIM AEAEELK
Q2FK29 in FASTA format

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