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UniProtKB/Swiss-Prot entry Q28560

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AVR2A_SHEEP
Primary accession number Q28560
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 63)
Name and origin of the protein
Protein name Activin receptor type-2A [Precursor]
Synonyms EC 2.7.11.30
Activin receptor type IIA
ACTR-IIA
Gene name
Name: ACVR2A
Synonyms: ACTRII, ACVR2
From
Ovis aries (Sheep) [TaxID: 9940] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Romney;
TISSUE=Ovarian follicle;
Tisdall D.J.;
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L19442; AAA91903.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001009293.1; -.
UniGene Oar.414
3D structure databases
HSSP P27038; 1BTE. [HSSP ENTRY / PDB]
SMR Q28560; 26-119.
ModBase Q28560.
Family and domain databases
InterPro IPR000333; Activin_II_recpt.
IPR015768; Activin_II_recpt_C.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
PANTHER PTHR23255:SF10; Activin_II_recpt_C; 1.
Pfam PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
PRINTS PR00653; ACTIVIN2R.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q28560.
Genome annotation databases
GeneID 443304; -.
Phylogenomic databases
HOVERGEN Q28560; -.
Other
ProtoNet Q28560.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19     Potential. 
CHAIN   20   513  494     Activin receptor type-2A. PRO_0000024400
TOPO_DOM   20   135  116     Extracellular (Potential). 
TRANSMEM   136   161  26     Potential. 
TOPO_DOM   162   513  352     Cytoplasmic (Potential). 
DOMAIN   192   485  294     Protein kinase. 
NP_BIND   198   206  9     ATP (By similarity). 
ACT_SITE   322   322        Proton acceptor (By similarity). 
BINDING   219   219        ATP (By similarity). 
CARBOHYD   43    43        N-linked (GlcNAc...) (Potential). 
CARBOHYD   66    66        N-linked (GlcNAc...) (Potential). 
DISULFID   30    60        By similarity. 
DISULFID   50    78        By similarity. 
DISULFID   85   104        By similarity. 
DISULFID   91   103        By similarity. 
DISULFID   105   110        By similarity. 
Sequence information
Length: 513 AA [This is the length of the unprocessed precursor] Molecular weight: 57768 Da [This is the MW of the unprocessed precursor] CRC64: 7231BF9E85CA57E3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC 

        70         80         90        100        110        120 
FATWKNISSS IDIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM 

       130        140        150        160        170        180 
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLV AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 

       190        200        210        220        230        240 
PPPSPLLGLK PLQLLEVKAR GGFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 

       250        260        270        280        290        300 
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 

       310        320        330        340        350        360 
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 

       370        380        390        400        410        420 
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFVEEIG 

       430        440        450        460        470        480 
QHPSLEDMQE VVVHKKKRPV LRDYWQKLAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 

       490        500        510 
QMQRLTNIIT TEDIVTVVTV VTNVDFPPKE SSL
Q28560 in FASTA format

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