ID   NOS2_CAPHI              Reviewed;         110 AA.
AC   Q28314;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-NOV-2008, entry version 56.
DE   RecName: Full=Nitric oxide synthase, inducible;
DE            EC=1.14.13.39;
DE   AltName: Full=Inducible NO synthase;
DE            Short=Inducible NOS;
DE            Short=iNOS;
DE   AltName: Full=NOS type II;
DE   Flags: Fragment;
GN   Name=NOS2;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Peripheral blood monocyte;
RX   MEDLINE=96183637; PubMed=8603979;
RA   Adler H., Adler B., Peveri P., Werner E.R., Wachter H., Peterhans E.,
RA   Jungi T.W.;
RT   "Differential regulation of inducible nitric oxide synthase production
RT   in bovine and caprine macrophages.";
RL   J. Infect. Dis. 173:971-978(1996).
CC   -!- FUNCTION: Produces nitric oxide (NO) which is a messenger molecule
CC       with diverse functions throughout the body.
CC   -!- CATALYTIC ACTIVITY: L-arginine + n NADPH + m O(2) = citrulline +
CC       nitric oxide + n NADP(+).
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- COFACTOR: Binds 1 FAD (By similarity).
CC   -!- COFACTOR: Binds 1 FMN (By similarity).
CC   -!- COFACTOR: Metrahydrobiopterin (BH4). May stabilize the dimeric
CC       form of the enzyme (By similarity).
CC   -!- ENZYME REGULATION: Regulated by calcium/calmodulin (By
CC       similarity).
CC   -!- SUBUNIT: Homodimer. Binds SLC9A3R1 (By similarity).
CC   -!- INDUCTION: By lipopolysaccharide (LPS).
CC   -!- SIMILARITY: Belongs to the NOS family.
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DR   EMBL; U29085; AAB02338.1; -; mRNA.
DR   HSSP; P35228; 4NOS.
DR   SMR; Q28314; 1-110.
DR   HOVERGEN; Q28314; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004517; F:nitric-oxide synthase activity; IEA:InterPro.
DR   GO; GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004030; NO_synthase_oxygenase_reg.
DR   Gene3D; G3DSA:3.90.340.10; NO_synthase_oxygenase_reg; 1.
DR   Pfam; PF02898; NO_synthase; 1.
DR   PROSITE; PS60001; NOS; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Calmodulin-binding; FAD; FMN; Heme; Iron; Metal-binding;
KW   NADP; Oxidoreductase.
FT   CHAIN        <1   >110       Nitric oxide synthase, inducible.
FT                                /FTId=PRO_0000170928.
FT   METAL        35     35       Iron (heme axial ligand) (By similarity).
FT   NON_TER       1      1
FT   NON_TER     110    110
SQ   SEQUENCE   110 AA;  12654 MW;  D72188FB257EC518 CRC64;
     VEAVTKEIET TGTYQLTGDE LIFATKQAWR NAPRCIGRIQ WSNLQVFDAR SCSTAQEMFE
     HICRHVRYAT NNGNIRSAIT VFPQRSDGKH DFRVWNAQLI RYAGYQMPDG
//