NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=B1868;
DOI=10.1016/0022-2836(92)90869-L; PubMed=1469718 [NCBI, ExPASy, EBI, Israel, Japan]
Hummel R., Noergaard P., Andreasen P.H., Neve S., Skjoedt K., Tornehave D., Kristiansen K.;
"Tetrahymena gene encodes a protein that is homologous with the liver-specific F-antigen and associated with membranes of the Golgi apparatus and transport vesicles.";
J. Mol. Biol. 228:850-861(1992).

Comments

CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O₂ = homogentisate + CO₂.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6 .
SIMILARITY: Belongs to the 4HPPD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M59429; AAA96492.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S27339; S27339.

3D structure databases

HSSP

P80064; 1CJX. [HSSP ENTRY / PDB]

ModBase

Q27203.

Family and domain databases

InterPro

IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.

PANTHER

PTHR11959; HPP_dOase; 1.

Pfam

PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF009283; HPP_dOase; 1.

TIGR01263; 4HPPD; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 404`	`404`	`4-hydroxyphenylpyruvate dioxygenase.`	`PRO_0000088396`
`METAL`	`197 197`		`Iron (By similarity).`
`METAL`	`280 280`		`Iron (By similarity).`
`METAL`	`364 364`		`Iron (By similarity).`

Sequence information

Length: 404 AA [This is the length of the unprocessed precursor]

Molecular weight: 46046 Da [This is the MW of the unprocessed precursor]

CRC64: 48DADC8AEE5D1837 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSENKDHVVV GYTEKPVGER PTGGKFLGYD HLHFWVGNAK QAAGWYTSRF GFEYYAYKGL 

        70         80         90        100        110        120 
ETGSREVATH VVRNKQGVTL AFSTPYGNDK DNQREMNQHQ SLHGDGVKDV AFAVEDCHSI 

       130        140        150        160        170        180 
YNKAIQRGAK CAYPPQDLKD EHGSVTIAAV HTYGEVIHTF IQRNDYKGFF MPGFVAHPLK 

       190        200        210        220        230        240 
DPLNNVLPDI SYNYVDHIVG NQPDNMMTSA ADWYEKTLDF HRFWSVDDSM IHTEFSSLRS 

       250        260        270        280        290        300 
IVMTDYDQKI KMPINEPADG KRKSQIQEYI DFYAGPGVQH IALNTSDVIN TVEGLRARGV 

       310        320        330        340        350        360 
EFLSIPTSYY DNLRKALTAQ TSITVKEDLD VLQKNHILVD YDEKGYLLQI FTKPVEDRPT 

       370        380        390        400 
LFYEIIQRNN HQGFGAGNFK SLFVSLELEQ EKRGNLTEIV KNIY

Q27203 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools