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UniProtKB/Swiss-Prot entry Q25417

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALDH2_LEITA
Primary accession number Q25417
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 48)
Name and origin of the protein
Protein name Aldehyde dehydrogenase, mitochondrial [Precursor]
Synonyms EC 1.2.1.3
ALDH class 2
P51
Gene name
Name: ALDH2
From
Leishmania tarentolae (Sauroleishmania tarentolae) [TaxID: 5689] 
Taxonomy Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania; lizard Leishmania.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 10-31.
STRAIN=UC;
DOI=10.1016/0166-6851(95)00023-T; PubMed=7630384 [NCBI, ExPASy, EBI, Israel, Japan]
Bringaud F., Peris M., Zen K.H., Simpson L.;
"Characterization of two nuclear-encoded protein components of mitochondrial ribonucleoprotein complexes from Leishmania tarentolae.";
Mol. Biochem. Parasitol. 71:65-79(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z31698; CAA83503.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S43184; S43184.
3D structure databases
HSSP P05091; 1O01. [HSSP ENTRY / PDB]
ModBase Q25417.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from electronic annotation from UniProtKB-KW).
GO:0004029; Molecular function: aldehyde dehydrogenase (NAD) activity (inferred from electronic annotation from EC).
GO:0003723; Molecular function: RNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q25417.
ProtoNet Q25417.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; RNA-binding; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     9  9     Mitochondrion. 
CHAIN   10   498  489     Aldehyde dehydrogenase, mitochondrial. PRO_0000007171
NP_BIND   242   247  6     NAD (By similarity). 
ACT_SITE   265   265        Proton acceptor (By similarity). 
ACT_SITE   299   299        Nucleophile (By similarity). 
SITE   166   166  1     Transition state stabilizer (By similarity). 
Sequence information
Length: 498 AA [This is the length of the unprocessed precursor] Molecular weight: 54252 Da [This is the MW of the unprocessed precursor] CRC64: 618D55F6ED5547EC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLRATLARLE MAPKVTHIQE KLLINGKFVP AVSGKTFEVV NPADEKVIAN VAEAEKADVD 

        70         80         90        100        110        120 
LAVKAARHAF ESFRMTDCQW RRNLMLRLAD ILEKNSKEMA ALESLDNGKP YEVALNVDVA 

       130        140        150        160        170        180 
LSVECFRYCA GLADKVNGTV PPRSGNFLGI VKRQPIGVCG QIIPWNFPLL MAAFKLSPAL 

       190        200        210        220        230        240 
AMGNTVVLKP AEQTPLTAVR LGEMVMEAGY PDGVLNILPG FGATAGSEIA RHMDVDKIAF 

       250        260        270        280        290        300 
TGSTAVGHQV MQMAAETNLK KVSLELGGKS ALIVCEDADL EEAAEVATTR VYFNTGQVCT 

       310        320        330        340        350        360 
ASSRIYVHES VYDEFVSRLR KNAEARKVGP GNDTGNNMGP LVSKKQHERV LGYIEDGVKA 

       370        380        390        400        410        420 
GATVVTGGKK IGDKGYFVQP TIFSDVKEDM RICKEEIFGP VTCVMKYKDM DEVVKRANDS 

       430        440        450        460        470        480 
IYGLAAGICT RSMDTALRYS TYLNAGTVWV NTWNNFCPSM PFGGFKQSGI GRELGKEVVD 

       490 
MYTEPKAIHF ASRSIVKP
Q25417 in FASTA format

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