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UniProtKB/Swiss-Prot entry Q22633

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HPPD_CAEEL
Primary accession number Q22633
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name 4-hydroxyphenylpyruvate dioxygenase
Synonyms EC 1.13.11.27
4-hydroxyphenylpyruvic acid oxidase
HPPDase
4HPPD
HPD
Gene name
Name: hpd-1
ORFNames: T21C12.2
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z50016; CAA90315.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T25063; T25063.
RefSeq NP_499324.1; -.
UniGene Cel.10002
3D structure databases
HSSP P80064; 1CJX. [HSSP ENTRY / PDB]
SMR Q22633; 7-367.
ModBase Q22633.
Organism-specific databases
WormBase WBGene00001993; hpd-1.
WormPep T21C12.2; CE02347. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q22633; -.
Ontologies
GO
GO:0040010; Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
QuickGo view.
Family and domain databases
InterPro IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.
PANTHER PTHR11959; HPP_dOase; 1.
Pfam PF00903; Glyoxalase; 2.
Pfam graphical view of domain structure.
PIRSF PIRSF009283; HPP_dOase; 1.
TIGRFAMs TIGR01263; 4HPPD; 1.
BLOCKS Q22633.
Genome annotation databases
Ensembl T21C12.2; Caenorhabditis elegans. [Contig view]
GeneID 176473; -.
KEGG cel:T21C12.2; -.
Other
ProtoNet Q22633.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   393  393     4-hydroxyphenylpyruvate dioxygenase. PRO_0000088395
METAL   182   182        Iron (By similarity). 
METAL   267   267        Iron (By similarity). 
METAL   350   350        Iron (By similarity). 
Sequence information
Length: 393 AA [This is the length of the unprocessed precursor] Molecular weight: 44383 Da [This is the MW of the unprocessed precursor] CRC64: B2D66424ED2CE998 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTTFDKGAKP DIGTFVAFDH VRFVVGNAKQ AAYWYCANFG FEPFAYKGLE TGSRITAQHA 

        70         80         90        100        110        120 
IRQDKIVFIF ESALLPDNSE LGNHLVQHGD GVKDVCFEVE DLDSIIAHAK AAGATIVHDI 

       130        140        150        160        170        180 
TEESDADGSI RYATLRTYGE TDHTLLERKN YRGAFLPGFK AHPMPATFFK TLPRVGLNFL 

       190        200        210        220        230        240 
DHCVGNQPDL QMDSAVQWYE KVLKFHRFWS VDDSMIHTEY SALRSIVVTN FEETIKMPIN 

       250        260        270        280        290        300 
EPATSDKKAI SQIQEYVDYY GGSGVQHIAL NTSDIITAIE ALRARGCEFL SIPSSYYDNL 

       310        320        330        340        350        360 
KERLAASSMV VKEDMDRLQK LHILVDFDEN GYLLQIFSKP CQDRPTLFLE IIQRQNHEGF 

       370        380        390 
GAGNFKALFE SIELEQTKRG NLFYDNVKDG NTK
Q22633 in FASTA format

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