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UniProtKB/Swiss-Prot entry Q22347

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACADM_CAEEL
Primary accession number Q22347
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 68)
Name and origin of the protein
Protein name Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Precursor]
Synonyms MCAD
EC 1.3.99.3
Gene name
ORFNames: T08G2.3
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U42838; AAB52493.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T16838; T16838.
RefSeq NP_510788.1; -.
UniGene Cel.378
3D structure databases
HSSP P11310; 1EGE. [HSSP ENTRY / PDB]
ModBase Q22347.
Protein-protein interaction databases
DIP DIP:25385N; -.
Organism-specific databases
WormBase WBGene00020366; T08G2.3.
WormPep T08G2.3; CE07473. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q22347; -.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR006091; Acyl-CoA_DHase/Oxase_M.
IPR006089; Acyl-CoA_DHase_CS.
IPR006092; Acyl-CoA_DHase_N.
IPR006090; Acyl-CoA_Oxase/DHase_1.
IPR013786; AcylCoA_DH/ox_N.
IPR013764; AcylCoA_oxidase/DH_1/2_C.
Graphical view of domain structure.
Gene3D G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.
Pfam PF00441; Acyl-CoA_dh_1; 1.
PF02770; Acyl-CoA_dh_M; 1.
PF02771; Acyl-CoA_dh_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00072; ACYL_COA_DH_1; 1.
PS00073; ACYL_COA_DH_2; 1.
BLOCKS Q22347.
Genome annotation databases
Ensembl T08G2.3; Caenorhabditis elegans. [Contig view]
GeneID 181757; -.
KEGG cel:T08G2.3; -.
Other
ProtoNet Q22347.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    15  15     Mitochondrion (By similarity). 
CHAIN   16   417  402     Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial. PRO_0000000507
NP_BIND   148   157  10     FAD (By similarity). 
NP_BIND   181   183  3     FAD (By similarity). 
NP_BIND   306   307  2     FAD (By similarity). 
NP_BIND   364   368  5     FAD (By similarity). 
NP_BIND   393   395  3     FAD (By similarity). 
REGION   268   271  4     Substrate binding (By similarity). 
ACT_SITE   391   391        Proton acceptor (By similarity). 
BINDING   157   157        Substrate; via carbonyl oxygen (By similarity). 
BINDING   392   392        Substrate; via amide nitrogen (By similarity). 
Sequence information
Length: 417 AA [This is the length of the unprocessed precursor] Molecular weight: 44818 Da [This is the MW of the unprocessed precursor] CRC64: 98CE260E72C521BF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLSRIATSSL GLSRSATGVI ATQSRQISFD LSETQKEIQD AALKFSKDVL VPNAAKFDES 

        70         80         90        100        110        120 
GEFPWEIVRQ AHSLGLMNPQ IPEKYGGPGM TTLETALIVE ALSYGCTGIQ LGIMGPSLAI 

       130        140        150        160        170        180 
APVYISGNEE QKKKYLGALA AEPIIASYCV TEPGAGSDVN GVKTKCEKKG DEYIINGSKA 

       190        200        210        220        230        240 
WITGGGHAKW FFVLARSDPN PKTPAGKAFT AFIVDGDTPG ITRGKKEKNM GQRCSDTRVI 

       250        260        270        280        290        300 
TFEDVRVPAE NVLGAPGAGF KVAMEAFDMT RPGVAAGALG LSWRCLDESA KYALERKAFG 

       310        320        330        340        350        360 
TVIANHQAVQ FMLADMAVNL ELARLITYKS ANDVDNKVRS SYNASIAKCF AADTANQAAT 

       370        380        390        400        410 
NAVQIFGGNG FNSEYPVEKL MRDAKIYQIY EGTSQIQRIV ISRMLLGHFA QNGTSRI
Q22347 in FASTA format

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