NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).

Comments

CATALYTIC ACTIVITY: L-cysteine + O₂ = 3-sulfinoalanine.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2 .
PTM: The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the ferrous ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen (By similarity).
SIMILARITY: Belongs to the cysteine dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U51993; AAB36852.2; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

T16488; T16488.

NP_508168.1; -.

3D structure databases

ModBase

Q20893.

Organism-specific databases

WormBase

WBGene00018986; F56F10.3.

WormPep

F56F10.3; CE28465. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

Q20893; -.

Family and domain databases

InterPro

IPR010300; Cys_dOase_I.
Graphical view of domain structure.

Pfam

PF05995; CDO_I; 1.
Pfam graphical view of domain structure.

BLOCKS

Q20893.

Genome annotation databases

Ensembl

F56F10.3; Caenorhabditis elegans. [Contig view]

GeneID

180434; -.

KEGG

cel:F56F10.3; -.

NMPDR

fig|6239.3.peg.22361; -.

Other

ProtoNet

Q20893.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Thioether bond.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 190`	`190`	`Cysteine dioxygenase.`	`PRO_0000206612`
`METAL`	`78 78`		`Iron; catalytic (By similarity).`
`METAL`	`80 80`		`Iron; catalytic (By similarity).`
`METAL`	`132 132`		`Iron; catalytic (By similarity).`
`CROSSLNK`	`85 149`		`3'-(S-cysteinyl)-tyrosine (Cys-Tyr) (By similarity).`

Sequence information

Length: 190 AA [This is the length of the unprocessed precursor]

Molecular weight: 21879 Da [This is the MW of the unprocessed precursor]

CRC64: 273A194DBFFA0C55 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY TRNLVDVGNG 

        70         80         90        100        110        120 
KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA WPRKRHVPLD ISENKTYGMN 

       130        140        150        160        170        180 
GVSYMNDELG LHRMENLSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK 

       190 
VDYRGSKNGN

Q20893 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools