ID   P5CR_CAEEL              Reviewed;         299 AA.
AC   Q20848;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-NOV-2008, entry version 51.
DE   RecName: Full=Putative pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   ORFNames=F55G1.9;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; U58750; AAB00645.1; -; Genomic_DNA.
DR   PIR; T29226; T29226.
DR   RefSeq; NP_501199.1; -.
DR   UniGene; Cel.12859; -.
DR   Ensembl; F55G1.9; Caenorhabditis elegans.
DR   GeneID; 177519; -.
DR   KEGG; cel:F55G1.9; -.
DR   NMPDR; fig|6239.3.peg.13938; -.
DR   WormBase; WBGene00018904; F55G1.9.
DR   WormPep; F55G1.9; CE07286.
DR   NextBio; 897180; -.
DR   ArrayExpress; Q20848; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Complete proteome; NADP; Oxidoreductase;
KW   Proline biosynthesis.
FT   CHAIN         1    299       Putative pyrroline-5-carboxylate
FT                                reductase.
FT                                /FTId=PRO_0000187321.
SQ   SEQUENCE   299 AA;  32057 MW;  75D2D6D32E0A5670 CRC64;
     MTIDTELTNG SSESVPFVFI GGGNMAAAII KGCQNKGFTP KSNIVIGVQT EKSAEKWRQL
     GYKNVFTNTL EMLERYSTAI YVICVKPQVF EEVVSSWPVN SRPEFIISVM AGVPLKVLNA
     KLPFVSGNTT IVRLMPNVAS SIGAGASTMC YEKNEKIMNQ DSHIELAREF AECVGTVELI
     PERCFNPAMA IGGSSPAWTF MYIESLADGA VAQGLGRAEA KRLAAQAVLG AAQMVLNSNS
     GFDIETQHFG SLKDMVCSPG GTTIEGVRAL EKNGFRYAVM EAVVAASTKA DEMAKSLAK
//