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UniProtKB/Swiss-Prot entry Q1WT04


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_LACS1
Primary accession number Q1WT04
Secondary accession numbers None
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on May 2, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 19)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: LSL_1139
From
Lactobacillus salivarius subsp. salivarius (strain UCC118) [TaxID: 362948] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0511060103; PubMed=16617113 [NCBI, ExPASy, EBI, Israel, Japan]
Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W.;
"Multireplicon genome architecture of Lactobacillus salivarius.";
Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000233; ABD99947.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_536030.1; -.
3D structure databases
ModBase Q1WT04.
Enzyme and pathway databases
BioCyc LSAL362948:LSL_1139-MON; -.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01511; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036500; GMP_red_Firmic; 1.
TIGRFAMs TIGR01306; GMP_reduct_2; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS Q1WT04.
Genome annotation databases
GeneID 3977879; -.
GenomeReviews CP000233_GR; LSL_1139.
KEGG lsl:LSL_1139; -.
Phylogenomic databases
HOGENOM Q1WT04; -.
Genome annotation databases
CMR Q1WT04; LSL_1139.
Other
ProtoNet Q1WT04.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   325  325     GMP reductase. PRO_0000292053
NP_BIND   203   226  24     NADP (Potential). 
ACT_SITE   174   174        Thioimidate intermediate (By similarity). 
Sequence information
Length: 325 AA [This is the length of the unprocessed precursor] Molecular weight: 35714 Da [This is the MW of the unprocessed precursor] CRC64: 253C67F02267DE36 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPVFDYEDIQ LVPNKCIVKS RSEVNTKVKF GPMTFKIPVV PANMQTIIDE NLAVWLAKNG 

        70         80         90        100        110        120 
YFYIMHRFYE NERVDFVKNM HDKGLFASIS VGVKPAEYDL IDELSQKNLV PEYITIDIAH 

       130        140        150        160        170        180 
GHSDTVINMI KHIKHKLPGV FVIAGNVGTP EAVRELENAG ADATKVGIGP GKACITKLKT 

       190        200        210        220        230        240 
GFGTGGWQLA AIRACAKAAS KPIVADGGIR NNGDIAKSIR FGASMCMIGS LFAGHDETPG 

       250        260        270        280        290        300 
DIIEKDGKKF KTYFGSASQY QKGEYKNVEG KKLLLPYKGK IADTLREMQE DLQSAISYAG 

       310        320 
GKELLALRKV DYVIVKNSIY NGDML 

Q1WT04 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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