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UniProtKB/Swiss-Prot entry Q1RJI5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUOA_RICBR
Primary accession number Q1RJI5
Secondary accession numbers None
Integrated into Swiss-Prot on January 9, 2007
Sequence was last modified on May 16, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 18)
Name and origin of the protein
Protein name NADH-quinone oxidoreductase subunit A
Synonyms EC 1.6.99.5
NADH dehydrogenase I subunit A
NDH-1 subunit A
Gene name
Name: nuoA
OrderedLocusNames: RBE_0398
From
Rickettsia bellii (strain RML369-C) [TaxID: 336407] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pgen.0020076; PubMed=16703114 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.;
"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens.";
PLoS Genet. 2:733-744(2006).
Comments
  • FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
  • CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
  • SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
  • SIMILARITY: Belongs to the complex I subunit 3 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000087; ABE04479.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_537568.1; -.
3D structure databases
ModBase Q1RJI5.
Enzyme and pathway databases
BioCyc RBEL336407:RBE_0398-MON; -.
Family and domain databases
InterPro IPR000440; Oxidored_q4.
Graphical view of domain structure.
PANTHER PTHR11058; Oxidored_q4; 1.
Pfam PF00507; Oxidored_q4; 1.
Pfam graphical view of domain structure.
BLOCKS Q1RJI5.
Genome annotation databases
GeneID 3996176; -.
GenomeReviews CP000087_GR; RBE_0398.
KEGG rbe:RBE_0398; -.
Phylogenomic databases
HOGENOM Q1RJI5; -.
Genome annotation databases
CMR Q1RJI5; RBE_0398.
Other
ProtoNet Q1RJI5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; Membrane; NAD; Oxidoreductase; Quinone; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   124  124     NADH-quinone oxidoreductase subunit A. PRO_0000271220
TRANSMEM   11    31  21     Potential. 
TRANSMEM   68    88  21     Potential. 
TRANSMEM   93   113  21     Potential. 
Sequence information
Length: 124 AA [This is the length of the unprocessed precursor] Molecular weight: 14415 Da [This is the MW of the unprocessed precursor] CRC64: F740E3B9971D10CB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLQNSELLQE YLPIAIFFGI ATLVSSLIMI LPNLLATKKY NKDKLEPYEC GFEPFDDARS 

        70         80         90        100        110        120 
KFDIRFYLVA ILFIIFDLEI TFLVPWAISL GTIGKIGFFS MMFFLFVLTI GFVYEWKKGA 


LDWE 

Q1RJI5 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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