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UniProtKB/Swiss-Prot entry Q1CT17


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_HELPH
Primary accession number Q1CT17
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on July 11, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 21)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: HPAG1_0838
From
Helicobacter pylori (strain HPAG1) [TaxID: 357544] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0603784103; PubMed=16788065 [NCBI, ExPASy, EBI, Israel, Japan]
Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.;
"The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression.";
Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000241; ABF84905.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_627579.1; -.
3D structure databases
SMR Q1CT17; 3-319.
ModBase Q1CT17.
Enzyme and pathway databases
BioCyc HPYL357544:HPAG1_0838-MON; -.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01511; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036500; GMP_red_Firmic; 1.
TIGRFAMs TIGR01306; GMP_reduct_2; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS Q1CT17.
Genome annotation databases
GeneID 4097866; -.
GenomeReviews CP000241_GR; HPAG1_0838.
KEGG hpa:HPAG1_0838; -.
Phylogenomic databases
HOGENOM Q1CT17; -.
Genome annotation databases
CMR Q1CT17; HPAG1_0838.
Other
ProtoNet Q1CT17.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   325  325     GMP reductase. PRO_0000294272
NP_BIND   203   226  24     NADP (Potential). 
ACT_SITE   174   174        Thioimidate intermediate (By similarity). 
Sequence information
Length: 325 AA [This is the length of the unprocessed precursor] Molecular weight: 35948 Da [This is the MW of the unprocessed precursor] CRC64: 105FA763C186FCC4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKVFDYEDVQ LIPNKCIVNS RSECDTTVIL GKHAFKMPIV PANMQTIINE PIAEFLAENG 

        70         80         90        100        110        120 
YFYIMHRFNG STRIPFVKKM KERQWISSIS VGVKKEEYLL IEELAKQGLT PDYITIDIAH 

       130        140        150        160        170        180 
GHSNSVIEMI QRIKTRLPET FVIAGNVGTP EAVRELENAG ADATKVGIGP GKVCITKIKT 

       190        200        210        220        230        240 
GFGTGGWQLA ALRWCAKAAR KPIIADGGIR THGDIAKSIR FGATMVMIGS LFAGHEESSG 

       250        260        270        280        290        300 
ETKIENGVAY KEYFGSASEF QKGEKKNVEG KKIWIQHKGS LKDTLVEMQQ DLQSSISYAG 

       310        320 
GRDLEAIRKV DYVIVKNSIF NGDTI 

Q1CT17 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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