ID   AL9A1_ORYLA             Reviewed;         505 AA.
AC   Q19A30;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   04-NOV-2008, entry version 21.
DE   RecName: Full=Aldehyde dehydrogenase family 9 member A1;
DE            EC=1.2.1.3;
GN   Name=aldh9A1; Synonyms=aldh9;
OS   Oryzias latipes (Medaka fish) (Japanese ricefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Atherinomorpha;
OC   Beloniformes; Adrianichthyidae; Oryziinae; Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=17236798; DOI=10.1016/j.cbpb.2006.11.006;
RA   Wang X., Zhu S., Khan I.A., Dasmahapatra A.K.;
RT   "Ethanol attenuates Aldh9 mRNA expression in Japanese medaka (Oryzias
RT   latipes) embryogenesis.";
RL   Comp. Biochem. Physiol. 146B:357-363(2007).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = an acid + NADH.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- TISSUE SPECIFICITY: Constitutively expressed in all organs tested:
CC       brain, eye, gill, GI, heart, liver, kidney, muscle, skin, testis
CC       and ovary.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; DQ535181; ABF83193.1; -; mRNA.
DR   RefSeq; NP_001098318.1; -.
DR   UniGene; Ola.6101; -.
DR   SMR; Q19A30; 6-505.
DR   Ensembl; ENSORLG00000014167; Oryzias latipes.
DR   GeneID; 100049493; -.
DR   HOVERGEN; Q19A30; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; NAD; Oxidoreductase.
FT   CHAIN         1    505       Aldehyde dehydrogenase family 9 member
FT                                A1.
FT                                /FTId=PRO_0000300626.
FT   NP_BIND     243    248       NAD (By similarity).
FT   ACT_SITE    265    265       Potential.
FT   ACT_SITE    299    299       Potential.
SQ   SEQUENCE   505 AA;  54482 MW;  2558A9F02C570638 CRC64;
     MSLATLDSMG GASTGSVTVT EQLNFWAGRR VGGRNSEHAE PVFEPATGRV LCQMVPCGAE
     EVDEAIMSAH AAYVQWSKKS GTERARVMLE AARIIRERRE KIAKLEVINN GKSITEALVD
     IDVAWQCIEY YAGVAGTLAG QHFQLPGGAF AYTRREPLGV CVGIGAWNYP FQIAACKSAP
     ALACGNAMVF KPSPFTPVTA VILAEIYKEA GVPDGLFCVV QGGAETGSLL CNHPKVAKVS
     FTGSVPTGKK VMEMSAKGVK QVTLELGGKS PLIIFKDCDL ENAVKGALMA NFLTQGQVCC
     NGTRVFVHKD ILPQFLEEVV KRTKAIAVGD PLLDSTRMGA LITKPHLEKV LGFVRQAKKE
     GGRVLCGGEP FVPSDPKLKG GYFMSPCILD NCRDDMTCVK EEIFGPVMSV LPFDTEEEVI
     RRANNTTFGL ASGVFTRDIS RAHRVAASLE AGTCFINNYN ISPVEVPFGG YKMSGFGREN
     GQVTIEYYSQ LKTVVVETGD VENYF
//