ID   BODG_CAEEL              Reviewed;         421 AA.
AC   Q19000;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   04-NOV-2008, entry version 48.
DE   RecName: Full=Probable gamma-butyrobetaine dioxygenase;
DE            EC=1.14.11.1;
DE   AltName: Full=Gamma-butyrobetaine,2-oxoglutarate dioxygenase;
DE   AltName: Full=Gamma-butyrobetaine hydroxylase;
DE            Short=Gamma-BBH;
GN   Name=gbh-1; ORFNames=D2089.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Catalyzes the formation of L-carnitine from gamma-
CC       butyrobetaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4-trimethylammoniobutanoate + 2-oxoglutarate +
CC       O(2) = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO(2).
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- COFACTOR: Ascorbate (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis.
CC   -!- SIMILARITY: Belongs to the gamma-BBH/TMLD family.
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DR   EMBL; Z36948; CAA85412.1; -; Genomic_DNA.
DR   PIR; T20380; T20380.
DR   RefSeq; NP_496305.1; -.
DR   UniGene; Cel.14890; -.
DR   Ensembl; D2089.5; Caenorhabditis elegans.
DR   GeneID; 174648; -.
DR   KEGG; cel:D2089.5; -.
DR   NMPDR; fig|6239.3.peg.7294; -.
DR   WormBase; WBGene00001522; gbh-1.
DR   WormPep; D2089.5; CE00940.
DR   NextBio; 884906; -.
DR   ArrayExpress; Q19000; -.
DR   GO; GO:0008336; F:gamma-butyrobetaine dioxygenase activity; IEA:EC.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single d...; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR012775; 2-oxoglut_dOase.
DR   InterPro; IPR003819; Taurine_dOase.
DR   Pfam; PF02668; TauD; 1.
DR   TIGRFAMs; TIGR02409; carnitine_bodg; 1.
PE   2: Evidence at transcript level;
KW   Carnitine biosynthesis; Complete proteome; Dioxygenase; Iron;
KW   Oxidoreductase.
FT   CHAIN         1    421       Probable gamma-butyrobetaine dioxygenase.
FT                                /FTId=PRO_0000207088.
SQ   SEQUENCE   421 AA;  48436 MW;  10949C4BF8262DF6 CRC64;
     MLSALLIRNI RNASKLASVA GPNSDRIVNV KWSDGKTGVF PLIWLRDTSP DPSTYTISPA
     MTARKLTMLE FDVEQNARKL WIDEDANCLK IEWESGVLSE FPSEWLKIRN PSDQEARRRR
     RKVYLFPEQT WGKAEIEGKL KKFSHEEFMK NEQVVHDFLQ AVCIDGIAVL KGAPQGVRGA
     VEAIGDRIGM IKRTHFGLVF EVSLKADASN MAYASNGGLP FHTDFPSLSH PPQLQMLHML
     QSAEEGGHSL FVDGFHVAEQ LRVEKPEIFK ILTTQSMEYI EEGYDVHEIN GKTIRFDYDM
     CARHKVIRLN DDGKVNKIQF GNAMRSWFYD CEPSKVQDVY RAMKTFTEYC YQPRNMLKFR
     LEDGDTVLWA NQRLLHTRDG FRNAPEKART LTGCYFDWDI VKSRVRFLRD KLSLEQNQPS
     A
//