NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).

Comments

FUNCTION: Catalyzes the formation of L-carnitine from gamma-butyrobetaine (By similarity).
CATALYTIC ACTIVITY: 4-trimethylammoniobutanoate + 2-oxoglutarate + O₂ = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO₂.
COFACTOR: Iron (By similarity).
COFACTOR: Ascorbate (By similarity).
PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis .
SIMILARITY: Belongs to the gamma-BBH/TMLD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z36948; CAA85412.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

T20380; T20380.

NP_496305.1; -.

3D structure databases

ModBase

Q19000.

Organism-specific databases

WormBase

WBGene00001522; gbh-1.

WormPep

D2089.5; CE00940. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

Q19000; -.

Family and domain databases

InterPro

IPR012775; 2-oxoglut_dOase.
IPR003819; Taurine_dOase.
Graphical view of domain structure.

Pfam

PF02668; TauD; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02409; carnitine_bodg; 1.

BLOCKS

Q19000.

Genome annotation databases

Ensembl

D2089.5; Caenorhabditis elegans. [Contig view]

GeneID

174648; -.

KEGG

cel:D2089.5; -.

NMPDR

fig|6239.3.peg.7294; -.

Other

ProtoNet

Q19000.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carnitine biosynthesis; Complete proteome; Dioxygenase; Iron; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 421`	`421`		`Probable gamma-butyrobetaine dioxygenase.`	`PRO_0000207088`

Sequence information

Length: 421 AA [This is the length of the unprocessed precursor]

Molecular weight: 48436 Da [This is the MW of the unprocessed precursor]

CRC64: 10949C4BF8262DF6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLSALLIRNI RNASKLASVA GPNSDRIVNV KWSDGKTGVF PLIWLRDTSP DPSTYTISPA 

        70         80         90        100        110        120 
MTARKLTMLE FDVEQNARKL WIDEDANCLK IEWESGVLSE FPSEWLKIRN PSDQEARRRR 

       130        140        150        160        170        180 
RKVYLFPEQT WGKAEIEGKL KKFSHEEFMK NEQVVHDFLQ AVCIDGIAVL KGAPQGVRGA 

       190        200        210        220        230        240 
VEAIGDRIGM IKRTHFGLVF EVSLKADASN MAYASNGGLP FHTDFPSLSH PPQLQMLHML 

       250        260        270        280        290        300 
QSAEEGGHSL FVDGFHVAEQ LRVEKPEIFK ILTTQSMEYI EEGYDVHEIN GKTIRFDYDM 

       310        320        330        340        350        360 
CARHKVIRLN DDGKVNKIQF GNAMRSWFYD CEPSKVQDVY RAMKTFTEYC YQPRNMLKFR 

       370        380        390        400        410        420 
LEDGDTVLWA NQRLLHTRDG FRNAPEKART LTGCYFDWDI VKSRVRFLRD KLSLEQNQPS 


A

Q19000 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools