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UniProtKB/Swiss-Prot entry Q18ER3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DP2L_HALWD
Primary accession number Q18ER3
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on July 25, 2006 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 23)
Name and origin of the protein
Protein name DNA polymerase II large subunit
Synonyms Pol II
EC 2.7.7.7
Contains Hwa polC 1 intein
     (Hwa pol II 1 intein)
Hwa polC 2 intein
     (Hwa pol II 2 intein)
Gene name
Name: polC
Synonyms: polA2
OrderedLocusNames: HQ3461A
From
Haloquadratum walsbyi (strain DSM 16790) [TaxID: 362976] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Haloquadratum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1186/1471-2164-7-169; PubMed=16820047 [NCBI, ExPASy, EBI, Israel, Japan]
Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F., Pfeiffer F., Oesterhelt D.;
"The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity.";
BMC Genomics 7:169-169(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AM180088; CAJ53557.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_659142.1; -.
3D structure databases
ModBase Q18ER3.
Enzyme and pathway databases
BioCyc HWAL362976:HQ3461A-MON; -.
Ontologies
GO
GO:0008408; Molecular function: 3'-5' exonuclease activity (inferred from electronic annotation from HAMAP).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from HAMAP).
GO:0003887; Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0004519; Molecular function: endonuclease activity (inferred from electronic annotation from InterPro).
GO:0000738; Biological process: DNA catabolic process, exonucleolytic (inferred from electronic annotation from HAMAP).
GO:0006261; Biological process: DNA-dependent DNA replication (inferred from electronic annotation from HAMAP).
GO:0016539; Biological process: intein-mediated protein splicing (inferred from electronic annotation from InterPro).
GO:0006314; Biological process: intron homing (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00324; atypical; 1.
PBIL [Tree]
InterPro IPR003586; Hedgehog_hint_C.
IPR003587; Hedgehog_hint_N.
IPR006142; INTEIN.
IPR004042; Intein_endonuc.
IPR006141; Intein_splicing_site.
IPR004475; PolC_DP2.
IPR016033; PolC_DP2_N.
Graphical view of domain structure.
Pfam PF03833; PolC_DP2; 1.
Pfam graphical view of domain structure.
PRINTS PR00379; INTEIN.
SMART SM00305; HintC; 2.
SM00306; HintN; 2.
SMART graphical view of domain structure.
TIGRFAMs TIGR01443; intein_Cterm; 2.
TIGR01445; intein_Nterm; 1.
TIGR00354; polC; 1.
PROSITE PS50818; INTEIN_C_TER; FALSE_NEG.
PS50819; INTEIN_ENDONUCLEASE; 2.
PS50817; INTEIN_N_TER; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 4194482; -.
GenomeReviews AM180088_GR; HQ3461A.
KEGG hwa:HQ3461A; -.
NMPDR fig|362976.6.peg.2460; -.
Phylogenomic databases
HOGENOM Q18ER3; -.
Genome annotation databases
CMR Q18ER3; HQ3461A.
Other
ProtoNet Q18ER3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Autocatalytic cleavage; Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Endonuclease; Exonuclease; Hydrolase; Intron homing; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Protein splicing; Repeat; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1    966  966     DNA polymerase II large subunit, 1st part (Potential). PRO_0000294680
CHAIN   967   1495  529     Hwa polC 1 intein (Potential). PRO_0000294681
CHAIN   1496   1524  29     DNA polymerase II large subunit, 2nd part (Potential). PRO_0000294682
CHAIN   1525   2068  544     Hwa polC 2 intein (Potential). PRO_0000294683
CHAIN   2069   2289  221     DNA polymerase II large subunit, 3rd part (Potential). PRO_0000294684
DOMAIN   1222   1367  146     DOD-type homing endonuclease 1. 
DOMAIN   1755   1911  157     DOD-type homing endonuclease 2. 
Sequence information
Length: 2289 AA [This is the length of the unprocessed precursor] Molecular weight: 255812 Da [This is the MW of the unprocessed precursor] CRC64: A5E70294203AFF05 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRDADKQYFE TLESHLEQAF ARARQAKGQG YDPKPEVEIP VARDMADRVE NILAIPDVAE 

        70         80         90        100        110        120 
RIRELDDERS REEVALELVT DFVEGTVGDY DTREGKIEGA VRTAVALLTE GVVAAPIEGI 

       130        140        150        160        170        180 
DRVEILSDDD GSEFVNVYYA GPIRSAGGTA QALSVLVADY ARSLLDIDEY SARTDETERY 

       190        200        210        220        230        240 
AEEVSLYDRE TGLQYSPKDK ETKFITKHMP IMLDGEATGN EEVSGYRDLE RVDTNAARGG 

       250        260        270        280        290        300 
MCLVLAEGIA LKAPKIQRYT RQLAEVEWPW LQDLIDDTIG SDEHSNNSVK NGEADIVKTD 

       310        320        330        340        350        360 
KDTNESETED GIDNDDYNDS GLEPANSPRA DATNKYLRDL IAGRPVFGHP SAAGAFRLRY 

       370        380        390        400        410        420 
GRARNHGFAT AGVHPATMHI VDDFIATGTQ LKTERPGKAG GVVPVDSIKG PTVRLANGDV 

       430        440        450        460        470        480 
RCINDPEEAE KLQNGVEKIL DLGEYLVNFG EFIENNHPLA PAAYVFEWWI QEFEASNADV 

       490        500        510        520        530        540 
QALRDDPTVD LESPTFENAM RWAKKHDIPL HPAYTYLWHD ISVTEFDHLA DAVAAGEITM 

       550        560        570        580        590        600 
NEVSDTNSAS GNTSLRANTN TDDTLTIDTT PAIRETMERL LIEHHQDSDS IHIPAWRALA 

       610        620        630        640        650        660 
LSLGIKIESD NDTGIGDRMW SLTDLSKHAR KQDDGKSAIA AVNEVAPFQV RERAPTRIGS 

       670        680        690        700        710        720 
RMGRPEKSED RDLSPAVHTL FPIGEAGGNQ RNLSDAAQSF GDNTERGQIS VQLGKRRCPY 

       730        740        750        760        770        780 
CETVGFELQC AECGRHTEPQ FVCRECESVL SPDESGRVHC DRCERDVTSA EWQDIDLHQR 

       790        800        810        820        830        840 
YRDALDRVDE RESSFEILKG VKGLTSSNKT PEPLEKGILR AKHGVSSFKD GTVRYDMTDL 

       850        860        870        880        890        900 
PVTAVRPKEL DVTAAHFREL GYQTDINGNP LQFDDQLVEL KVQDIVLPDG AAEHMMKTAD 

       910        920        930        940        950        960 
FVDDLLEQFY ELNQFYQIDE RDDLIGELVF GMAPHTSAAV VGRIVGFTSA AVGYAHPYFH 

       970        980        990       1000       1010       1020 
AAKRRNCFHP ETKIWFRDTD NEWHHETIQT FVEDRLDDPE IDAVGTLVQE VDDNTDREIS 

      1030       1040       1050       1060       1070       1080 
VPSIDDNGNE RLQSVTAVSK HRAPNHLVQI ETISGREITI TPDHEMHIFE QGNLVSKQAS 

      1090       1100       1110       1120       1130       1140 
KITSGEYAVI PKRLQTISPS SHTPQHDLLR EFLTRDELTA DRLIIHTSDP VRLCNRVFPE 

      1150       1160       1170       1180       1190       1200 
EVTSCKDAVE IMQNTACHLD KNKETLIGWL GEGRIPVALL RGFVETDEAL LMSIPDDVQI 

      1210       1220       1230       1240       1250       1260 
GLRGEKVRID RHIGFTEELT SLLGYYAAAG IVHTQTNPIS YESAQQEQSR ITFYNIDTQT 

      1270       1280       1290       1300       1310       1320 
QTDLLNALNS VFEIEPIQYN LDGEILGVPG ELIRRVFDTV FDVGTQPSHK RIPQALFDAS 

      1330       1340       1350       1360       1370       1380 
ESHITSYLRC FFSTHDSLTT DTRDISATTV SREFKEDIIA ALRRLGITAE VTTQQSRSVP 

      1390       1400       1410       1420       1430       1440 
EVLPDWYAID DITHHDADNS LNLTRSYVIS IASSDAVTLQ RDRQAQEQIK YDAQGLIANN 

      1450       1460       1470       1480       1490       1500 
NAIHQSRQVT DGGRKDYITE PITDIEYVDA DIDYTYCLTV SETHSLIVND LSQKQCDGDE 

      1510       1520       1530       1540       1550       1560 
DCVMLLMDGL LNFSREYLPD KRGGSVAADS RLVAVSPDDK IVFTTIEDFW KKLNTPIERN 

      1570       1580       1590       1600       1610       1620 
GKFRKRTCVS EGWQTYAFDE NHEASLRPIE KAIRYTADES EQLRRITTQL GRSLDITDEH 

      1630       1640       1650       1660       1670       1680 
SLFRYDDGIE EVAGDDLTAG DIIVAPRTLD VEVTQTTLDL SEYIHDNERC PSEQTGSGEL 

      1690       1700       1710       1720       1730       1740 
NLASKSAISD SRNKETPGVT HNILPQRSKF TDEMTTLSPT AVGGLESEQN ETLRVGESTG 

      1750       1760       1770       1780       1790       1800 
AIERYINVDD SFGWLLGQFI AQRSISTDAL TMTVHTAAEK HAERIVATSD SVFGIKPTVN 

      1810       1820       1830       1840       1850       1860 
SIERGYEIVF PSVFDTIVSG LTAKEQSEPE QDVDHTHTDE IGIPECILHA PDDIVLSFLQ 

      1870       1880       1890       1900       1910       1920 
GFILAENAQR KGNAASEASE MVSESETTVT LETPSVGVKD GLVFLCHRLG VITDISEKSG 

      1930       1940       1950       1960       1970       1980 
EEYSVHFEES RYTVSIATEG KTNPLDQILN GERPTMPEGV SVPVPDALLT IHESIANSPH 

      1990       2000       2010       2020       2030       2040 
IDQVIPDTVV QQETVSLETL QSLLTGLSTV DLPAQLEAKR DELTLLTEGD LSYLRVESVE 

      2050       2060       2070       2080       2090       2100 
CVDYDGYLYD LQVGGEPVFT ANWLYAHNSM DAPLVMSSRI DPSEIDDEAH NMDIVRQYPR 

      2110       2120       2130       2140       2150       2160 
EFYEATRRME DPDEWEEEVT IAEEYLDTDN EYTGFNHTHD TTDIAAGPDL SAYKTLDSMM 

      2170       2180       2190       2200       2210       2220 
DKMDAQLELA RKLRAVDETD VAERVIEYHF LPDLIGNLRA FSRQQTRCLD CGESYRRMPL 

      2230       2240       2250       2260       2270       2280 
TGECRECGGR VNLTVHEGSV NKYMDTAIHI AEEFDCREYT KQRLEVLERS LESIFEDDTN 


KQSGIADFM
Q18ER3 in FASTA format

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