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UniProtKB/Swiss-Prot entry Q18C47

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_CLOD6
Primary accession number Q18C47
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on July 25, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 22)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: CD1526
From
Clostridium difficile (strain 630) [TaxID: 272563] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/ng1830; PubMed=16804543 [NCBI, ExPASy, EBI, Israel, Japan]
Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N., Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H., Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N., Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A., Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K., Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L., Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
"The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome.";
Nat. Genet. 38:779-786(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AM180355; CAJ68391.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001088027.1; -.
3D structure databases
ModBase Q18C47.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q18C47.
ProtoNet Q18C47.
Genome annotation databases
GeneID 4914653; -.
GenomeReviews AM180355_GR; CD1526.
KEGG cdf:CD1526; -.
NMPDR fig|1496.1.peg.3393; -.
Phylogenomic databases
HOGENOM Q18C47; -.
Genome annotation databases
CMR Q18C47; CD1526.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   421  421     Dihydroorotase. PRO_1000024080
METAL   60    60        Zinc 1 (By similarity). 
METAL   62    62        Zinc 1 (By similarity). 
METAL   141   141        Zinc 1; via carbamate group (By similarity). 
METAL   141   141        Zinc 2; via carbamate group (By similarity). 
METAL   178   178        Zinc 2 (By similarity). 
METAL   231   231        Zinc 2 (By similarity). 
METAL   304   304        Zinc 1 (By similarity). 
MOD_RES   141   141        N6-carboxylysine (By similarity). 
Sequence information
Length: 421 AA [This is the length of the unprocessed precursor] Molecular weight: 45976 Da [This is the MW of the unprocessed precursor] CRC64: 1B97667E07506FDB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MILIKNGRVI DPKSQRDENI DLIIKENKIY KIGKFDESDE YEKIIDASGN VVAPGLVDVH 

        70         80         90        100        110        120 
VHFRDPGFTY KEDIESGAKS AARGGFTTVI CMANTNPIVD NEDTFNYVKE KSKNACINVL 

       130        140        150        160        170        180 
QAAAITKGFE GKELVDMEAL KKAGVPGFTD DGLPLMDSNL IMEAMIKAKE LDVPLSFHEE 

       190        200        210        220        230        240 
DPSLVGNPGV NAGKVASELG LKGASSVAED VMVARDCMLA LKTGAKVDIQ HISSGVSVDM 

       250        260        270        280        290        300 
VRFAKYLGAT VVAEASPHHF TLTEEDVLEF GTNAKMNPPL RSKWDRDKII EGLNDGTIEI 

       310        320        330        340        350        360 
IATDHAPHSK EEKDREFIKA PSGIIGLETS LALGITNLVH KNHLSMMQLI EKMSINPAKL 

       370        380        390        400        410        420 
YNLNIGFIEE GAVADIVIFN PEEEWTVESF VSKADNSPFK GKSLYGKVNY TICNGEIVYN 


A
Q18C47 in FASTA format

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