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UniProtKB/Swiss-Prot entry Q18164

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DPYD_CAEEL
Primary accession number Q18164
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on May 16, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 65)
Name and origin of the protein
Protein name Probable dihydropyrimidine dehydrogenase [NADP+]
Synonyms DHPDHase
DPD
EC 1.3.1.2
Dihydrouracil dehydrogenase
Dihydrothymine dehydrogenase
Gene name
ORFNames: C25F6.3
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U39742; AAK39195.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T15616; T15616.
RefSeq NP_508927.2; -.
UniGene Cel.5583
3D structure databases
HSSP Q28943; 1GTE. [HSSP ENTRY / PDB]
ModBase Q18164.
Protein-protein interaction databases
DIP DIP:25332N; -.
Organism-specific databases
WormBase WBGene00016103; C25F6.3.
WormPep C25F6.3; CE38489. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q18164; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0017113; Molecular function: dihydropyrimidine dehydrogenase (NADP+) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0006214; Biological process: thymidine catabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006212; Biological process: uracil catabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR000759; Adrndx_reductase.
IPR013785; Aldolase_TIM.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR012285; Fum_reductase_C.
IPR001327; Pyr_OxRdtase_NAD_bd.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.
Pfam PF01180; DHO_dh; 1.
PF00037; Fer4; 2.
PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00469; PNDRDTASEII.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 3.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q18164.
Genome annotation databases
Ensembl C25F6.3; Caenorhabditis elegans. [Contig view]
GeneID 180818; -.
KEGG cel:C25F6.3; -.
NMPDR fig|6239.3.peg.23326; -.
Other
ProtoNet Q18164.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; FAD; Flavoprotein; FMN; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1059  1059     Probable dihydropyrimidine dehydrogenase [NADP+]. PRO_0000079997
DOMAIN   84    118  35     4Fe-4S ferredoxin-type 1. 
DOMAIN   955    987  33     4Fe-4S ferredoxin-type 2. 
DOMAIN   989   1019  31     4Fe-4S ferredoxin-type 3. 
METAL   964    964        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   967    967        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   970    970        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   974    974        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   998    998        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   1001   1001        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   1004   1004        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   1008   1008        Iron-sulfur 2 (4Fe-4S) (Potential). 
Sequence information
Length: 1059 AA [This is the length of the unprocessed precursor] Molecular weight: 115301 Da [This is the MW of the unprocessed precursor] CRC64: E5DDEEE1ED145262 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTPKPNTTSP TNNLPLLSKD SPDIESLLIL NPKVQDKANA VPSAVTKKNK HNWKRNEEKG 

        70         80         90        100        110        120 
CGSTCGESKL KNDFRDIKHT TLSERGALKE AMRCLKCADA PCQKSCPTQL DVKSFITSIS 

       130        140        150        160        170        180 
NKNYYGAARQ ILSDNPLGLT CGMICPTSDL CVGSCNLQAS EEGAINIGGL QQYACDVFKQ 

       190        200        210        220        230        240 
MNVRQIVSKE VRENRNASHK EQVALIGCGP ASISCASFLA RLGYTDITIY EKRAYIGGLS 

       250        260        270        280        290        300 
SAEIPQFRLP YDVVDFEIQL ARDIGVQIET NRPLGKDGLT LAKLKEQGAA AVFIGIGNPE 

       310        320        330        340        350        360 
PKIDPLFEGL TIENGFYTSK NYLPAVAAAS KPGMCGCKRT PLPTMRGRVV VLGAGDTAMD 

       370        380        390        400        410        420 
CATSALRCGA SRVTIAFRKG FTGIRAVPEE MEAAKEEKCE FLPFSAPRKI NVKDGRIVSI 

       430        440        450        460        470        480 
EFNKTEQDDN GKWYEDEEQI VILKCDYVIS AFGSTLKEDA VLSALQPCQL NKWGGIEVDS 

       490        500        510        520        530        540 
TTQQTSEKWV FAGGDVAGVA ETTVESVNDG KIAAWNMHRY IQSLHGNQVS ETPELPQFFT 

       550        560        570        580        590        600 
PIDEVDISVD MCGVKFENPF GLASAPPTTS GPMCRRAFEQ GWGFILTKTY GLDKDLVTNV 

       610        620        630        640        650        660 
SPRIVRGSTS GPLYGPNQGS FMNIELISEK SCEYWLQCIR ELKRDHPTKI VIASIMCVYN 

       670        680        690        700        710        720 
KADWIELATK SEEAGADILE LNLSCPHGMG EKGMGLACGQ SPEIVKEICR WVRACVKIPF 

       730        740        750        760        770        780 
FPKMTPNITD VREIARAARD GGASGVTATN TVSSLMHMKA DGNAWPAIGS TKRTTYGGMS 

       790        800        810        820        830        840 
GSAIRPIAMK AVSSIANELD GFPIMATGGI ESAETGLGFL MAGASVLQVC SAVQNQDFTV 

       850        860        870        880        890        900 
VDDYCTGLKA LLYLSGAESL KNWDGQSPPI EKHQKGKPIL LQGQKKMPFF GKYRDEREKL 

       910        920        930        940        950        960 
EAIKLSESNL LDTENYHFAS RPDTQVSRVP TVEDVIGKAL PRIGPYVTLD NQEQKVAIID 

       970        980        990       1000       1010       1020 
DDMCINCGKC YMTCNDSGYQ AITFDPVTHQ PHVTEDDCTG CTLCYSVCPI PECIEMVPRT 

      1030       1040       1050 
GPWKAPKRGV KPSVEPGTPK VVKVDQRGRV ILDTTGGMQ
Q18164 in FASTA format

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View entry in raw text format (no links)
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