ID   P5CR2_BOVIN             Reviewed;         320 AA.
AC   Q17QJ7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   16-DEC-2008, entry version 22.
DE   RecName: Full=Pyrroline-5-carboxylate reductase 2;
DE            Short=P5C reductase 2;
DE            Short=P5CR 2;
DE            EC=1.5.1.2;
GN   Name=PYCR2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; BC118324; AAI18325.1; -; mRNA.
DR   RefSeq; NP_001068649.1; -.
DR   UniGene; Bt.7679; -.
DR   SMR; Q17QJ7; 1-275.
DR   Ensembl; ENSBTAG00000005835; Bos taurus.
DR   GeneID; 504987; -.
DR   KEGG; bta:504987; -.
DR   HOVERGEN; Q17QJ7; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Amino-acid biosynthesis; NADP; Oxidoreductase;
KW   Phosphoprotein; Proline biosynthesis.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    320       Pyrroline-5-carboxylate reductase 2.
FT                                /FTId=PRO_0000270819.
FT   MOD_RES       2      2       N-acetylserine (By similarity).
FT   MOD_RES     304    304       Phosphoserine (By similarity).
SQ   SEQUENCE   320 AA;  33630 MW;  4B43FC3EFC552F91 CRC64;
     MSVGFIGAGQ LACALARGFT AAGILSAHKI IASSPEMDLP TVSALRKMGV NLTRSNKETV
     RHSDVLFLAV KPHIIPFILD EIGADVQARH IVVSCAAGVT ISSVEKKLMA FQPAPKVIRC
     MTNTPVLVRE GATVYATGTH ALVEDGQLLE QLMSSVGFCT EVEEDLIDAV TGLSGSGPAY
     AFMALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLDS EQHPGQLKDN VCSPGGATIH
     ALHFLESGGF RSLLINAVEA SCIRTRELQS MADQEKISPA ALKKTLLDRV KLESPTVTTL
     TPTSSGKLLT RSPVPGGKKD
//