[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Fetal muscle; NIH - Mammalian Gene Collection (MGC) project; Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

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Cross-references

Sequence databases

EMBL

BC118324; AAI18325.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001068649.1; -.

UniGene

Bt.7679

3D structure databases

SMR

Q17QJ7; 1-275.

ModBase

Q17QJ7.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGR00112; proC; 1.

PS00521; P5CR; 1.

Genome annotation databases

Ensembl

ENSBTAG00000005835; Bos taurus. [Contig view]

GeneID

504987; -.

KEGG

bta:504987; -.

Phylogenomic databases

HOVERGEN

Q17QJ7; -.

Other

ProtoNet

Q17QJ7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 320`	`320`		`Pyrroline-5-carboxylate reductase 2.`	`PRO_0000270819`

Sequence information

Length: 320 AA [This is the length of the unprocessed precursor]

Molecular weight: 33630 Da [This is the MW of the unprocessed precursor]

CRC64: 4B43FC3EFC552F91 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVGFIGAGQ LACALARGFT AAGILSAHKI IASSPEMDLP TVSALRKMGV NLTRSNKETV 

        70         80         90        100        110        120 
RHSDVLFLAV KPHIIPFILD EIGADVQARH IVVSCAAGVT ISSVEKKLMA FQPAPKVIRC 

       130        140        150        160        170        180 
MTNTPVLVRE GATVYATGTH ALVEDGQLLE QLMSSVGFCT EVEEDLIDAV TGLSGSGPAY 

       190        200        210        220        230        240 
AFMALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLDS EQHPGQLKDN VCSPGGATIH 

       250        260        270        280        290        300 
ALHFLESGGF RSLLINAVEA SCIRTRELQS MADQEKISPA ALKKTLLDRV KLESPTVTTL 

       310        320 
TPTSSGKLLT RSPVPGGKKD

Q17QJ7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools