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UniProtKB/Swiss-Prot entry Q17M80


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MMSA_AEDAE
Primary accession number Q17M80
Secondary accession numbers None
Integrated into Swiss-Prot on December 4, 2007
Sequence was last modified on July 25, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 19)
Name and origin of the protein
Protein name Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [Precursor]
Synonyms MMSDH
Malonate-semialdehyde dehydrogenase [acylating]
EC 1.2.1.27
EC 1.2.1.18
Gene name
ORFNames: AAEL001134
From
Aedes aegypti (Yellowfever mosquito) [TaxID: 7159] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae; Culicini; Aedes; Stegomyia.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Liverpool;
DOI=10.1126/science.1138878; PubMed=17510324 [NCBI, ExPASy, EBI, Israel, Japan]
Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
"Genome sequence of Aedes aegypti, a major arbovirus vector.";
Science 316:1718-1723(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CH477208; EAT47764.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001652386.1; -.
UniGene Aae.2920
3D structure databases
ModBase Q17M80.
Ontologies
GO
GO:0018478; Molecular function: malonate-semialdehyde dehydrogenase (acetylating) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0004491; Molecular function: methylmalonate-semialdehyde dehydrogenase (acylating) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0019859; Biological process: thymine metabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006573; Biological process: valine metabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010061; MeMal-semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF27; MMSDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01722; MMSDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
BLOCKS Q17M80.
Genome annotation databases
GeneID 5568558; -.
KEGG aag:AaeL_AAEL001134; -.
VectorBase AAEL001134; Aedes aegypti.
Other
ProtoNet Q17M80.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   521        Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. PRO_0000312823
NP_BIND   196   200  5     NAD (Potential). 
NP_BIND   248   253  6     NAD (Potential). 
ACT_SITE   304   304        Nucleophile (By similarity). 
BINDING   404   404        NAD (Potential). 
Sequence information
Length: 521 AA [This is the length of the unprocessed precursor] Molecular weight: 56572 Da [This is the MW of the unprocessed precursor] CRC64: 9FC4A9E85D5F39A7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MALVRLLGVE CRNALQRSYS TASVPTTKMF IDGKFVDSKT TEWIDLHDPA TNKVVTRVPK 

        70         80         90        100        110        120 
CTQDEMESAV ESSKKAFKTW SQTSILGRQQ VMFKLQHLIR NNMSELAKNI TKEQGKTLVD 

       130        140        150        160        170        180 
AEGDVLRGLQ VVEHCCSITS LQMGETVPNI AKDMDTYSYT LPLGVTAGIC PFNFPAMIPL 

       190        200        210        220        230        240 
WMFPVAITCG NTSIIKPSER VPGATMMLME LLNEAGCPPG VVNVIHGAHD AVNFICDNPT 

       250        260        270        280        290        300 
IKAVSFVGSD QAGKYIYERA GRNGKRVQSN MGAKNHGVIM ADANKENTLN QLAGAAFGAA 

       310        320        330        340        350        360 
GQRCMALSTA VFVGEAKQWI PDLVERARKL KVNAGHVPGT DVGPVISPQS KQRINELVES 

       370        380        390        400        410        420 
GVKEGAKLVL DGRSIKVENF ENGNFVGPTI LTDVSTNMKC YTEEIFGPVL VCLTVDTVDE 

       430        440        450        460        470        480 
AVEMINNNPY GNGTAIFTTN GATARKFVNE IDVGQVGVNV PIPVPLPMFS FTGSRGSFMG 

       490        500        510        520 
DCHFYGKQGV KFYTQTKTVT QLWREGDVSH TKAAVAMPTM K 

Q17M80 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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