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UniProtKB/Swiss-Prot entry Q17EN4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HOT_AEDAE
Primary accession number Q17EN4
Secondary accession numbers None
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on July 25, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 21)
Name and origin of the protein
Protein name Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial [Precursor]
Synonyms HOT
EC 1.1.99.24
Gene name
ORFNames: AAEL003729
From
Aedes aegypti (Yellowfever mosquito) [TaxID: 7159] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae; Culicini; Aedes; Stegomyia.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Liverpool;
DOI=10.1126/science.1138878; PubMed=17510324 [NCBI, ExPASy, EBI, Israel, Japan]
Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
"Genome sequence of Aedes aegypti, a major arbovirus vector.";
Science 316:1718-1723(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CH477280; EAT44958.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001664064.1; -.
UniGene Aae.6969
3D structure databases
ModBase Q17EN4.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from sequence or structural similarity from UniProtKB).
GO:0047988; Molecular function: hydroxyacid-oxoacid transhydrogenase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0015993; Biological process: molecular hydrogen transport (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001670; Fe_AlcDHase.
Graphical view of domain structure.
Pfam PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.
PROSITE PS00913; ADH_IRON_1; FALSE_NEG.
PS00060; ADH_IRON_2; FALSE_NEG.
BLOCKS Q17EN4.
Genome annotation databases
GeneID 5578877; -.
KEGG aag:AaeL_AAEL003729; -.
VectorBase AAEL003729; Aedes aegypti.
Other
ProtoNet Q17EN4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   462        Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial. PRO_0000323003
Sequence information
Length: 462 AA [This is the length of the unprocessed precursor] Molecular weight: 50140 Da [This is the MW of the unprocessed precursor] CRC64: 294DCCE1FDF80BA1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MMSKARISSL MKVISSGSCS CPAHSRSSTG GLNVSSENEY AFEMSSSTIR YGPGVSKELG 

        70         80         90        100        110        120 
HDLQNLNAKN VCIVTDRNVA KLNSVKVAFD SLTRCGIQYQ VYDETRVEPT DQSLLHAAEY 

       130        140        150        160        170        180 
ARQNKFDSFV AIGGGSVIDT CKVANLFSAD REAEFLDYVN APIGKAKEVN VKLKPLIAVP 

       190        200        210        220        230        240 
TTAGTGSETT GVVIFDYKPL HAKTGISSKY LRPQLGLIDP LHTLSQPEKV AAYCGFDVFC 

       250        260        270        280        290        300 
HALESFTAIP YTERGSAPMN PNLRPPYQGS NPISDVWARF ALKIIRENFI SAVFNQDDLK 

       310        320        330        340        350        360 
ARSNMHLAST MAGVGFGNAG VHLCHGLSYP ISGHVKKFVP DGYSGDHPII PHGLSVVMTA 

       370        380        390        400        410        420 
PAVFKFTAAS CPERHLEAAE LLGANVSKAN RNDAGSILSD VVRQYMYKLK IENGLDSLGF 

       430        440        450        460 
TRDDIQSLVK GTLPQERITK LAPRAQTEED LASLFENSMT VY 

Q17EN4 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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